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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Serious Treatment Related Adverse Drug Reactions amongst Anti-Retroviral Naïve MDR-TB Patients
PLoS ONE, Volume 8, No. 4, Article e58817, Year 2013
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Description
Background: Globally treatment outcomes for multidrug-resistant Mycobacterium tuberculosis (MDR-TB) remain poor and this is compounded by high drug toxicity. Little is known about the influence of adverse drug reactions (ADRs) on treatment outcomes in South Africa. Methods: We evaluated the impact of severe ADRs among a prospective cohort of MDR-TB patients in South Africa (2000-2004). The HIV-infected study participants were anti-retroviral naïve. Results: Of 2,079 patients enrolled, 1,390 (66.8%) were included in this analysis based on known HIV test results (39.1% HIV-infected). At least one severe ADR was reported in 83 (6.9%) patients with ototoxicity being the most frequent ADR experienced (38.9%). Conclusions: We found that being HIV-infected but antiretroviral naïve did not increase occurrence of SADRs in patients on second-line anti-tuberculosis drugs. Early screening and proactive management of ADRs in this patient population is essential, especially given the rollout of decentralized care and the potential for overlapping toxicity of concomitant MDR-TB and HIV treatment. © 2013 Van der Walt et al.
Authors & Co-Authors
van der Walt, Martie L.
South Africa, Tygerberg
South African Medical Research Council
Lancaster, Johanna
South Africa, Tygerberg
South African Medical Research Council
Odendaal, Ronel
South Africa, Tygerberg
South African Medical Research Council
Davis, Jeanne Garcia
United States, Baltimore
Johns Hopkins School of Nursing
Shean, Karen P.
South Africa, Tygerberg
South African Medical Research Council
Farley, Jason E.
United States, Baltimore
Johns Hopkins School of Nursing
Statistics
Citations: 50
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1371/journal.pone.0058817
e-ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
South Africa