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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils
Journal of Immunology, Volume 182, No. 7, Year 2009
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Description
CLEC-2 is a member of the "dectin-1 cluster" of C-type lectin-like receptors and was originally thought to be restricted to platelets. In this study, we demonstrate that murine CLEC-2 is also expressed by peripheral blood neutrophils, but only weakly by bone marrow or elicited inflammatory neutrophils. On circulating neutrophils, CLEC-2 can mediate phagocytosis of Ab-coated beads and the production of proinflammatory cytokines, including TNF-α, in response to the CLEC-2 ligand, rhodocytin. CLEC-2 possesses a tyrosine-based cytoplasmic motif similar to that of dectin-1, and we show using chimeric analyses that the activities of this receptor are dependent on this tyrosine. Like dectin-1, CLEC-2 can recruit the signaling kinase Syk in myeloid cells, however, stimulation of this pathway does not induce the respiratory burst. These data therefore demonstrate that CLEC-2 expression is not restricted to platelets and that it functions as an activation receptor on neutrophils. Copyright © 2009 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Kerrigan, Ann M.
South Africa, Cape Town
University of Cape Town
Dennehy, Kevin M.
South Africa, Cape Town
University of Cape Town
Germany, Tubingen
Eberhard Karls Universität Tübingen
Mourão-Sá, Diego S.
United Kingdom, London
Cancer Research uk
Faro-Trindade, Inês
South Africa, Cape Town
University of Cape Town
Willment, Janet Anne
South Africa, Cape Town
University of Cape Town
Taylor, Philip Russel
United Kingdom, Cardiff
Cardiff University School of Medicine
Eble, J. A.
Germany, Frankfurt am Main
Universitätsklinikum Frankfurt
Reis E Sousa, Caetano E.
United Kingdom, London
Cancer Research uk
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 136
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.4049/jimmunol.0802808
ISSN:
00221767
e-ISSN:
15506606