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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A human gene responsible for neurosensory, non-syndromic recessive deafness is a candidate homologue of the mouse sh-1 gene
Human Molecular Genetics, Volume 3, No. 6, Year 1994
Notification
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Description
The identification of mouse models for the various forms of human neurosensory non-syndromic recessive deafness would constitute a major advance in the study of human deafness. Here we describe the localization of a human gene for neurosensory, non-syndromic recessive deafness (NSRD2) to chromosome 11q13.5 by linkage analysis of a highly consanguineous family. A maximum lod score of 10.63 (θ = 0.018) was obtained for the microsatellite marker D11S527. Homozygosity mapping refined the localization of NSRD2 to a 6 cM interval also containing the olfactory marker protein (OMP) gene. The murine homologue of OMP is tightly linked to the autosomal recessive deafness gene sh-1. These results, and clinical data, suggest that NSRD2 is the human homologue of the mouse sh-1 gene. © 1994 Oxford University Press.
Authors & Co-Authors
Guilford, Parry
France, Paris
Institut Pasteur, Paris
Ayadi, Hammadi
Tunisia, Sfax
Faculty of Medicine of Sfax
Blanchard, Stéphane
France, Paris
Institut Pasteur, Paris
Chaïb, Hassan
France, Paris
Institut Pasteur, Paris
Paslier, Denis Le
France, Paris
Fondation Jean Dausset - Ceph
Weissenbach, Jean S.
France, Paris
Institut Pasteur, Paris
France, Evry
Généthon
Drira, Mohamed Mokhtar
Tunisia, Sfax
Chu Habib Bourguiba
Petit, Christine
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 8
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1093/hmg/3.6.989
ISSN:
09646906
Research Areas
Genetics And Genomics