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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The binding site on ICAM-1 for plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site
Cell, Volume 68, No. 1, Year 1992
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Description
The intercellular adhesion molecule-1 (ICAM-1, CD54) is one of three putative endothelial receptors that mediate in vitro cytoadherence of P. falciparum-infected erythrocytes. Since cytoadherence to postcapillary venular endothelium is thought to be a major factor in the virulence of P. falciparum malaria, we have examined the interaction between ICAM-1 and the P. falciparum-infected cell, and have compared it with the interaction to the physiological counter receptor, the leukocyte integrin LFA-1. Our results demonstrate that the malaria-binding site resides in the first two domains of the ICAM-1 molecule and overlaps, but is distinct from, the LFA-1 site. © 1992.
Authors & Co-Authors
Berendt, Anthony R.
United Kingdom, Oxford
John Radcliffe Hospital
Craig, Alister Gordon
United Kingdom, Oxford
John Radcliffe Hospital
Bates, Paul A.
United Kingdom, London
Cancer Research uk
Marsh, Kevin
United Kingdom, Oxford
John Radcliffe Hospital
Newbold, Chris I.
United Kingdom, Oxford
John Radcliffe Hospital
Statistics
Citations: 240
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/0092-8674(92)90207-S
ISSN:
00928674
Research Areas
Infectious Diseases