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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Divergent mortality for male and female recipients of low-titer and high-titer measles vaccines in rural Senegal
American Journal of Epidemiology, Volume 138, No. 9, Year 1993
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Description
The female/male mortality ratio among unimmunized children and children vaccinated with standard or high-titer measles vaccines was examined for all children born in the period 1985-1991 in a rural area of Senegal. The female/male mortality ratio from 9 months to 5 years of age for unvaccinated children was 0.94 (95% confidence interval (Cl) 0.75-1.19), significantly different from the ratio of 0.64 (95% Cl 0.48-0.85) for recipients of the Schwarz standard measles vaccine (p=0.040). In the 4-year period, where high-titer measles vaccines were used in the study area, the female/male mortality ratio was 1.33 (95% Cl 1.00-1.78) for recipients of high-titer Edmonston-Zagreb or Schwarz vaccines compared with 0.67 (95% Cl 0.42-1.07) for recipients of the Schwarz standard vaccine (p=0.013). Hence, the Schwarz standard and high-titer measles vaccines have divergent sex-specific effects on mortality throughout childhood. Further studies of the underlying mechanisms are needed. © 1993 by The Johns Hopkins University School of Hygene and Public Health.
Authors & Co-Authors
Aaby, Peter
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Denmark, Copenhagen
Statens Serum Institut
Samb, Badara
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Simondon, François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Knudsen, Kim Mark
Denmark, Copenhagen
Statens Serum Institut
Denmark, Copenhagen
Københavns Universitet
Coll-Seck, Anna Marie
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Bennett, John V.
United States, Atlanta
Task Force for Child Survival and Development
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 95
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1093/oxfordjournals.aje.a116912
ISSN:
00029262
Research Areas
Infectious Diseases
Maternal And Child Health
Study Locations
Senegal
Participants Gender
Male
Female