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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Snake venomics: Comparative analysis of the venom proteomes of the Tunisian snakes Cerastes cerastes, Cerastes vipera and Macrovipera lebetina
Proteomics, Volume 5, No. 16, Year 2005
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Description
The protein composition of the crude venoms of the three most important vipers of Tunisia was analyzed by RP-HPLC, N-terminal sequence analysis, MALDI-TOF mass determination, and ingel tryptic digestion followed by PMF and CID-MS/MS of selected peptide ions in a quadrupole-linear IT instrument. Our results show that the venom proteomes of Cerastes cerastes, Cerastes vipera, and Macrovipera lebetina are composed of proteins belonging to a few protein families. However, each venom showed distinct degree of protein composition complexity. The three venoms shared a number of protein classes though the relative occurrence of these toxins was different in each snake species. On the other hand, the venoms of the Cerastes species and Macrovipera lebetina each contained unique components. The comparative proteomic analysis of Tunisian snake venoms provides a comprehensible catalogue of secreted proteins, which may contribute to a deeper understanding of the biological effects of the venoms, and may also serve as a starting point for studying structure-function correlations of individual toxins. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
Authors & Co-Authors
Bazaa, Amine
Tunisia, Tunis
Institut Pasteur de Tunis
Marrakchi, Naziha
Tunisia, Tunis
Institut Pasteur de Tunis
El-Ayeb, Mohamed E.
Tunisia, Tunis
Institut Pasteur de Tunis
Sanz, Libia
Spain, Valencia
Csic - Instituto de Biomedicina de Valencia Ibv
Calvete, Juan J.
Spain, Valencia
Csic - Instituto de Biomedicina de Valencia Ibv
Statistics
Citations: 119
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1002/pmic.200402024
ISSN:
16159853
Study Locations
Tunisia