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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
MTHFR functional genetic variation and methotrexate treatment response in rheumatoid arthritis: A meta-analysis
Pharmacogenomics, Volume 15, No. 4, Year 2014
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Description
Aim: To date, functional MTHFR SNPs have been tested for their impact on low-dose methotrexate (MTX) response in small rheumatoid arthritis (RA) cohorts. We sought to test their effect in the single largest cohort studied to date, and undertook a meta-analysis utilizing stringent study inclusion criteria. Materials & methods: RA patients treated with MTX monotherapy from the Yorkshire Early Arthritis Register (YEAR) were genotyped using RFLP assays, and tested for association with treatment efficacy. Studies for meta-analysis were screened by a set of stringent inclusion criteria. Results & conclusion: rs1801131 and rs1801133 were not associated with response to MTX in the YEAR cohort, nor did they affect the probability of achieving a low disease activity state. A meta-analysis of comparable studies found no association with these SNPs. MTHFR SNPs rs1801131 and rs1801133 are unlikely to have a clinically meaningful effect on the first 6 months of MTX treatment in early RA. © 2014 Future Medicine Ltd.
Authors & Co-Authors
Morgan, Michael D.L.
United Kingdom, Leeds
St James's University Hospital
Al-Shaarawy, Nashwa
Egypt, Ismailia
Faculty of Medicine
Martin, Steve
United Kingdom, Leeds
St James's University Hospital
Robinson, James I.
United Kingdom, Leeds
St James's University Hospital
Twigg, Sarah
United Kingdom, Leeds
Chapel Allerton Hospital
Magdy, Awadalla A.
Egypt, Ismailia
Faculty of Medicine
Omar, Aziza Sayed
Egypt, Ismailia
Faculty of Medicine
Ghattas, M. H.
Egypt, Ismailia
Faculty of Medicine
Emery, Paul D.
United Kingdom, Leeds
St James's University Hospital
United Kingdom, Leeds
Chapel Allerton Hospital
Barrett, J. H.
United Kingdom, Leeds
Chapel Allerton Hospital
United Kingdom, Leeds
St James's University Hospital
Morgan, Ann W.
United Kingdom, Leeds
St James's University Hospital
United Kingdom, Leeds
Chapel Allerton Hospital
Statistics
Citations: 11
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.2217/pgs.13.235
ISSN:
14622416
e-ISSN:
17448042
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cohort Study
Study Approach
Systematic review