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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Microfluidics-based diagnostics of infectious diseases in the developing world
Nature Medicine, Volume 17, No. 8, Year 2011
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Description
One of the great challenges in science and engineering today is to develop technologies to improve the health of people in the poorest regions of the world. Here we integrated new procedures for manufacturing, fluid handling and signal detection in microfluidics into a single, easy-to-use point-of-care (POC) assay that faithfully replicates all steps of ELISA, at a lower total material cost. We performed this 'mChip' assay in Rwanda on hundreds of locally collected human samples. The chip had excellent performance in the diagnosis of HIV using only 1 Î 1/4l of unprocessed whole blood and an ability to simultaneously diagnose HIV and syphilis with sensitivities and specificities that rival those of reference benchtop assays. Unlike most current rapid tests, the mChip test does not require user interpretation of the signal. Overall, we demonstrate an integrated strategy for miniaturizing complex laboratory assays using microfluidics and nanoparticles to enable POC diagnostics and early detection of infectious diseases in remote settings. © 2011 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Chin, Curtis D.
United States, New York
Columbia University
Laksanasopin, Tassaneewan
United States, New York
Columbia University
Cheung, Yuk Kee
United States, New York
Columbia University
Steinmiller, David
United States, Woburn
Claros Diagnostics
Linder, Vincent
United States, Woburn
Claros Diagnostics
Parsa, Hesam
United States, New York
Columbia University
Wang, Jennifer
United States, New York
Columbia University
Moore, Hannah
United States, New York
Columbia University
Rouse, Robert
United States, New York
Columbia University
Umviligihozo, Gisele
Rwanda, Kigali
Rwanda Zambia Hiv Research Group
Karita, Etienne
Rwanda, Kigali
Rwanda Zambia Hiv Research Group
Mwambarangwe, Lambert
Rwanda, Kigali
Projet Ubuzima
Braunstein, Sarah L.
United States, New York
Mailman School of Public Health
van de Wijgert, Janneke H.H.M.
Rwanda, Kigali
Projet Ubuzima
Netherlands, Amsterdam
Universiteit Van Amsterdam
Sahabo, Ruben
United States, New York
Mailman School of Public Health
Justman, Jessica E.
United States, New York
Mailman School of Public Health
El-Sadr, W. M.
United States, Woburn
Claros Diagnostics
Sia, Samuel K.
United States, New York
Columbia University
Statistics
Citations: 18
Authors: 18
Affiliations: 6
Identifiers
Doi:
10.1038/nm.2408
ISSN:
10788956
e-ISSN:
1546170X
Research Areas
Infectious Diseases
Study Locations
Rwanda