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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cervicovaginal overproduction of specific igg to human immunodeficiency virus (hiv) contrasts with normal or impaired iga local response in hiv infection
Journal of Infectious Diseases, Volume 172, No. 3, Year 1995
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Description
Paired sera and cervicovaginal secretions (CVS) from 30 women infected with human immunodeficiency virus (HIV) type 1 (before AIDS) were analyzed for IgG and IgA antibodies to HIV and for IgG, IgA, and human serum albumin. Subjects were compared with 30 age-matched healthy controls. In HIV-infected women, cervicovaginal immunoglobulins were markedly increased, and IgG predominated. An increased immunoglobulin transudation was implicated, since cervicovaginal albumin levels were 2.3-fold above those of normal controls. Furthermore, IgG excretion by reference to albumin was increased 1.9-fold, whereas the IgA secretion tended to decrease, suggesting a possible enhanced local IgG synthesis. Mean IgG and IgA anti-HIV antibody titers were, respectively, 30- and 12-fold higher in serum than in CVS, but their mean specific activities were higher in CVS than in serum, suggesting a local synthesis of both isotypes. The IgA antibody response to HIV remained poor compared with the strong IgG response. © 1975 The University of Chicago Press.
Authors & Co-Authors
Bélec, Laurent
France, Paris
Hopital Broussais
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Dupré, Thiérry
France, Paris
Hopital Broussais
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Prazuck, Thiérry
France, Paris
Hopital Broussais
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Tévi-Bénissan, Carol
France, Paris
Hopital Broussais
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Jean-Marie, Kanga
France, Paris
Hopital Broussais
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Pathey, Olivier
France, Paris
Hopital Broussais
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Lü, Xusheng
France, Paris
Hopital Broussais
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Pillot, Jacques
France, Paris
Hopital Broussais
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Statistics
Citations: 121
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1093/infdis/172.3.691
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Infectious Diseases
Participants Gender
Female