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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Correlation between the DNA global methylation status and progesterone receptor expression in normal endometrium, endometrioid adenocarcinoma and precursors
Virchows Archiv, Volume 445, No. 2, Year 2004
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Description
Endometrial carcinomas are the most common malignancy of the female genital tract and the third most common cancer in women. Progesterone and oestrogen receptors (PRs, ERs) are the most widely documented prognostic and predictive factors in endometrioid adenocarcinoma. Besides the hormonal pathway involved in the progression of preneoplastic and neoplastic lesions, alterations of the DNA methylation status have been shown to be an early signal of tumorigenesis. In this study, we show that in normal endometrium, during the proliferative phase, DNA methylation and PR expression are high, with a significant decline towards the end of the secretory phase and a gradual increase in non-atypical and atypical endometrial hyperplasia; they reach their highest level in grade I, then decrease significantly in grade-II and grade-III endometrioid adenocarcinomas. During each stage, a significant positive correlation is observed between DNA methylation and PR (P<0.0001). The strong parallelism between DNA methylation and PR expression precludes establishing a precise determination regarding the timing of these events, clearly involved in the genesis of endometrioid adenocarcinoma. © Springer-Verlag 2004.
Authors & Co-Authors
Ghabreau, Lina
France, Lyon
Hopital Edouard Herriot
Roux, Jean Paul
France, Paris
Inserm
Niveleau, Alain
France, Saint Martin D'heres
Université Grenoble Alpes
Fontanière, Bernard
France, Lyon
Le Centre Régional de Lutte Contre le Cancer Léon Bérard
Mahé, Cédric
France, Lyon
Centre International de Recherche Sur le Cancer
Mokni, Moncef
Tunisia, Sousse
Hopital Farhat Hached Sousse
Frappart, Lucien
France, Lyon
Hopital Edouard Herriot
France, Paris
Inserm
Statistics
Citations: 50
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1007/s00428-004-1059-4
ISSN:
09456317
Research Areas
Cancer
Genetics And Genomics
Sexual And Reproductive Health
Participants Gender
Female