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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Kaposi sarcoma incidence in the Swiss HIV Cohort Study before and after highly active antiretroviral therapy
British Journal of Cancer, Volume 99, No. 5, Year 2008
Notification
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Description
Between 1984 and 2006, 12 959 people with HIV/AIDS (PWHA) in the Swiss HIV Cohort Study contributed a total of 73 412 person-years (py) of follow-up, 35 551 of which derived from PWHA treated with highly active antiretroviral therapy (HAART). Five hundred and ninety-seven incident Kaposi sarcoma (KS) cases were identified of whom 52 were among HAART users. Cox regression was used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (CI). Kaposi sarcoma incidence fell abruptly in 1996-1998 to reach a plateau at 1.4 per 1000 py afterwards. Men having sex with men and birth in Africa or the Middle East were associated with KS in both non-users and users of HAART but the risk pattern by CD4 cell count differed. Only very low CD4 cell count (<50 cells μl-1) at enrolment or at HAART initiation were significantly associated with KS among HAART users. The HR for KS declined steeply in the first months after HAART initiation and continued to be low 7-10 years afterwards (HR, 0.06; 95% CI, 0.02-0.17). Thirty-three out of 52 (63.5%) KS cases among HAART users arose among PWHA who had stopped treatment or used HAART for less than 6 months. © 2008 Cancer Research UK.
Authors & Co-Authors
Franceschi, Silvia F.
France, Lyon
Centre International de Recherche Sur le Cancer
Dal Maso, Luigino
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Rickenbach, Martin
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Hirschel, B. J.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Cavassini, Matthias L.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Elzi, Luigia
Switzerland, Basel
Universitätsspital Basel
Jundt, Gernot
Switzerland, Basel
Basel Cancer Registry
Mueller, Nicolas J.
Switzerland, Zurich
Universitatsspital Zurich
Clifford, Gary M.
France, Lyon
Centre International de Recherche Sur le Cancer
Battegay, Manuel
Unknown Affiliation
Bernasconi, Enos
Unknown Affiliation
Böni, Jürg
Unknown Affiliation
Bucher, Heiner C.
Unknown Affiliation
Bürgisser, Ph
Unknown Affiliation
Cattacin, Sandro
Unknown Affiliation
Cavassini, Matthias
Unknown Affiliation
Dubs, Rolf W.
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Fischer, Marek
Unknown Affiliation
Flepp, Markus J.
Unknown Affiliation
Fontana, Adriano
Unknown Affiliation
Francioli, Patrick B.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Furrer, Hansjakob
Unknown Affiliation
Fux, Christoph Andreas
Unknown Affiliation
Gorgievski, Meri
Unknown Affiliation
Günthard, Hüldrych Fritz
Unknown Affiliation
Hirsch, Hans H.
Unknown Affiliation
Hirschel, B.
Unknown Affiliation
Hösli, Irene Mathilde
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kaiser, Laurent K.
Unknown Affiliation
Karrer, Urs
Unknown Affiliation
Kind, Christian H.
Unknown Affiliation
Klimkait, Thomas
Unknown Affiliation
Ledergerber, Bruno
Unknown Affiliation
Martinetti, Gladys
Unknown Affiliation
Martinez, Begogna
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Nadal, David
Unknown Affiliation
Opravil, Milos
Unknown Affiliation
Paccaud, Fred Michel
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Rauch, Andri
Unknown Affiliation
Regenass, Stephan
Unknown Affiliation
Rudin, Christoph
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Schültze, Detlev
Unknown Affiliation
Schüpbach, Jörg Rg
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Taffé, Patrick
Unknown Affiliation
Telenti, Amalio
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Vernazza, Pietro Luigi
Unknown Affiliation
Weber, Rainer
Unknown Affiliation
Yerly, Sabine T.B.D.
Unknown Affiliation
Statistics
Citations: 119
Authors: 55
Affiliations: 7
Identifiers
Doi:
10.1038/sj.bjc.6604520
ISSN:
15321827
Research Areas
Cancer
Environmental
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Male