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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis of chalcone derivatives as potential anti-diabetic agents
Bioorganic and Medicinal Chemistry Letters, Volume 22, No. 12, Year 2012
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Description
Chalcones bearing electron donating or electron withdrawing substitutions were prepared and their glucose uptake activity was evaluated. Chalcone derivatives were synthesized in one step protocol with high purity and yield. Chalcones with chloro, bromo, iodo and hydroxy substitutions at position 2 on A-ring exhibited the highest activity with glucose medium concentration (210 to 236 mg/dl) compared to pioglitazone and rosiglitazone (230 and 263 mg/dl, respectively). Also chalcones with iodo substitution at position 3 on A-ring were comparably active (≤ 238 mg/dl). The structure-activity relationship of the tested chalcones was studied and the findings were supported statistically. © 2012 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Hsieh, Chiting
Taiwan, Kaohsiung
Kaohsiung Medical University
Hsieh, Tusty Jiuan
Taiwan, Kaohsiung
College of Medicine
El-Shazly, Mohamed
Taiwan, Kaohsiung
Kaohsiung Medical University
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Chuang, Dawei
Taiwan, Kaohsiung
Kaohsiung Medical University
Tsai, Yihong
Taiwan, Kaohsiung
Kaohsiung Medical University
Yen, Chiaoting
Taiwan, Kaohsiung
Kaohsiung Medical University
Wu, Shoufang
Taiwan, Kaohsiung
Kaohsiung Medical University
Wu, Yangchang
Taiwan, Kaohsiung
Kaohsiung Medical University
Taiwan, Taichung
China Medical University
Taiwan, Taichung
China Medical University Hospital
Chang, Fangrong
Taiwan, Kaohsiung
Kaohsiung Medical University
Statistics
Citations: 120
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.bmcl.2012.04.108
ISSN:
0960894X
e-ISSN:
14643405