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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Innate and adaptive immune responses during acute M. tuberculosis infection in adult household contacts in Kampala, Uganda
American Journal of Tropical Medicine and Hygiene, Volume 86, No. 4, Year 2012
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Description
Contacts of active pulmonary tuberculosis (TB) patients are at risk for Mycobacterium tuberculosis (MTB) infection. Because most infections are controlled, studies during MTB infection provide insight into protective immunity. We compared immune responses of adult household contacts that did and did not convert the tuberculin skin test (TST). Innate and adaptive immune responses were measured by whole blood assay. Responses of TST converters (TSTC) were compared with persistently TST negative contacts (PTST-) and contacts who were TST+ at baseline (TST+). TLR-2, TLR-4, and IFN-γR responses to IFN-γ did not differ between the groups, nor did γδ T cell responses. T cell responses to MTB antigens differed markedly among TSTC, PTST-, and TST+ contacts. Thus, no differences in innate responses were found among the three household contact groups. However, adaptive T cell responses to MTB antigens did differ before and during MTB infection among PTST-, TSTC, and TST+ contacts. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Mahan, C. Scott
United States, Cleveland
Metrohealth Medical Center Cleveland
Zalwango, Sarah K.
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Uganda-cwru Research Collaboration
Thiel, Bonnie A.
United States, Cleveland
Case Western Reserve University
Malone, La Shaunda L.
United States, Cleveland
Case Western Reserve University
Chervenak, Keith A.
United States, Cleveland
Case Western Reserve University
Baseke, Joy
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Uganda-cwru Research Collaboration
Dobbs, Dennis
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Uganda-cwru Research Collaboration
Stein, Catherine M.
United States, Cleveland
Case Western Reserve University
Mayanja, Harriet K.
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Uganda-cwru Research Collaboration
Joloba, Moses Lutaakome
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Uganda-cwru Research Collaboration
Whalen, Christopher Curtis
United States, Athens
University of Georgia
Boom, W. Henry
United States, Cleveland
Case Western Reserve University
Statistics
Citations: 38
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2012.11-0553
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Uganda