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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Gender-specific associations between insulin resistance, hypertension, and markers of inflammation among adult Saudis with and without diabetes mellitus type 2
Advances in Medical Sciences, Volume 55, No. 2, Year 2010
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Description
Purpose: In view of the important roles of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and the acute phase reactant C-reactive protein (CRP) in glucose metabolism and pathogenesis of diabetes mellitus type 2 (DMT2), we assessed gender-specific differences and relative associations of these inflammatory biomarkers to insulin resistance (IR) and risk markers for DMT2.Materials and Methods: Serum levels of TNF-α, IL-6 and CRP were determined in 119 clinically diagnosed DMT2 cases, 114 non-DMT2 subjects with IR, and 97 age-matched controls. Fasting blood samples were collected and serum glucose levels, lipid profile, and inflammatory markers were analyzed.Results: In women, a significant association between elevated levels of IL-6 and risk of developing IR [Odds ratio (OR), 4.389, 95 % Confidence Interval (CI) 1.6-11.52, p = 0.004] was found. Significant associations were also found between elevated levels of CRP and risk of hypertension only in female subjects [OR (95% CI) 2.153 (1.04-4.53), p = 0.046]. While, in male subjects, a significant association between elevated levels of TNF-α and risk of developing IR [OR (95% CI) 2.32 (1.09-4.93), p = 0.029] was found.Conclusion: The present study showed apparent gender differences in the association of IL-6, CRP, and TNF-a with risks of IR and hypertension, and this could be attributed to sexual dimorphism in fat distribution. © Medical University of Bialystok, Poland.
Authors & Co-Authors
Al-Daghri, N. Mohammad
Saudi Arabia, Riyadh
College of Sciences
Al-Attas, Omar Salem
Saudi Arabia, Riyadh
College of Sciences
Alokail, Majed Saleh
Saudi Arabia, Riyadh
College of Sciences
Alkharfy, Khalid Mohammad
Saudi Arabia, Riyadh
College of Pharmacy
Shaik, Noor Ahmad
Saudi Arabia, Riyadh
College of Sciences
Draz, Hossam M.
Saudi Arabia, Riyadh
College of Sciences
Bamakhramah, Ahmed
Saudi Arabia, Riyadh
College of Sciences
Sabico, Shaun
Saudi Arabia, Riyadh
College of Sciences
Statistics
Citations: 18
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.2478/v10039-010-0052-1
ISSN:
18961126
e-ISSN:
18984002
Research Areas
Cancer
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Case-Control Study
Participants Gender
Male
Female