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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Hydrocortisone nanosuspensions for ophthalmic delivery: A comparative study between microfluidic nanoprecipitation and wet milling
Journal of Controlled Release, Volume 149, No. 2, Year 2011
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Description
Recently, drug nanosuspensions have shown a potential for ophthalmic delivery. In this study, a hydrocortisone (HC) nanosuspension (NS) was developed using microfluidic nanoprecipitation as a recent, simple and cost-effective bottom-up technique of drug nanonization. For comparison, a second HC NS was prepared by top-down wet milling procedures. The produced nanosuspensions were characterized for particle size, shape and zeta potential. HC nanosuspensions of approximately 300 nm particle size were produced by adjusting experimental conditions of the two processing techniques. Results of X-ray diffraction and differential scanning calorimetry revealed that HC maintained the crystalline structure upon milling, while predominant amorphous particles were generated after precipitation. Ocular bioavailability of HC nanosuspensions was assessed in albino rabbits using HC solution as a control. A sustained drug action was maintained up to 9 h for the nanosuspensions compared to 5 h for the drug solution. The precipitated and milled NS achieved comparable AUC0-9h values of 28.06 ± 4.08 and 30.95 ± 2.2, respectively, that were significantly (P < 0.05) higher than that of HC solution (15.86 ± 2.7). After 2 months storage at room temperature, the milled HC NS showed good stability with no discernable changes in particle size, whereas the particle size of the precipitated HC NS increased to 440 nm. © 2010 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Ali, Hany Saleh M.
United Kingdom, Bradford
University of Bradford
Egypt, Asyut
Faculty of Pharmacy
York, Peter
United Kingdom, Bradford
University of Bradford
Ali, Ahmed Mahmoud Abdelhaleem
Egypt, Beni Suef
Faculty of Pharmacy
Blagden, Nicholas
United Kingdom, Bradford
University of Bradford
Statistics
Citations: 148
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.jconrel.2010.10.007
ISSN:
01683659
Research Areas
Health System And Policy