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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Contribution of genetic background and clinical risk factors to low-trauma fractures in human immunodeficiency virus (HIV)-positive persons: The Swiss HIV Cohort Study
Open Forum Infectious Diseases, Volume 3, No. 2, Year 2016
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Description
Background. The impact of human genetic background on low-trauma fracture (LTF) risk has not been evaluated in the context of human immunodeficiency virus (HIV) and clinical LTF risk factors.Methods. In the general population, 6 common single-nucleotide polymorphisms (SNPs) associate with LTF through genome-wide association study. Using genome-wide SNP arrays and imputation, we genotyped these SNPs in HIV-positive, white Swiss HIV Cohort Study participants. We included 103 individuals with a first, physician-validated LTF and 206 controls matched on gender, whose duration of observation and whose antiretroviral therapy start dates were similar using incidence density sampling. Analyses of nongenetic LTF risk factors were based on 158 cases and 788 controls.Results. A genetic risk score built from the 6 LTF-associated SNPs did not associate with LTF risk, in both models including and not including parental hip fracture history. The contribution of clinical LTF risk factors was limited in our dataset.Conclusions. Genetic LTF markers with a modest effect size in the general population do not improve fracture prediction in persons with HIV, in whom clinical LTF risk factors are prevalent in both cases and controls. © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Authors & Co-Authors
Junier, Thomas
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Biver, Emmanuel
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Ledergerber, Bruno
Switzerland, Zurich
Universität Zürich
Bartha, István
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Kovari, Helen
Switzerland, Zurich
Universität Zürich
Schmid, Patrick
Switzerland, St Gallen
Kantonsspital St.gallen
Fux, Christoph Andreas
Switzerland, Aarau
Kantonsspital Aarau
Bernasconi, Enos
Switzerland, Bellinzona
Ente Ospedaliero Cantonale
Weber, Rainer
Switzerland, Zurich
Universität Zürich
Fellay, Jacques
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Tarr, Philip E.
Switzerland, Basel
Universitat Basel
Aubert, Vincent
Unknown Affiliation
Battegay, Manuel
Unknown Affiliation
Bernasconi, Enos
Unknown Affiliation
Böni, Jürg
Unknown Affiliation
Braun, Dominique Laurent
Unknown Affiliation
Bucher, Heíner C.C.
Unknown Affiliation
Burton-Jeangros, Claudine
Unknown Affiliation
Calmy, Alexandra
Unknown Affiliation
Cavassini, Matthias
Unknown Affiliation
Dollenmaier, Guenter
Unknown Affiliation
Egger, Matthias
Unknown Affiliation
Elzi, Luigia
Unknown Affiliation
Fehr, Jan Sven
Unknown Affiliation
Furrer, Hansjakob
Unknown Affiliation
Gorgievski, Meri
Unknown Affiliation
Günthard, Hüldrych Fritz
Unknown Affiliation
Haerry, David Hans Ulrich
Unknown Affiliation
Hasse, Barbara Katharina
Unknown Affiliation
Hirsch, Hans H.
Unknown Affiliation
Hoffmann, Matthias
Unknown Affiliation
Hösli, Irene Mathilde
Unknown Affiliation
Kahlert, Christian R.
Unknown Affiliation
Kaiser, Laurent K.
Unknown Affiliation
Keiser, Olivia
Unknown Affiliation
Klimkait, Thomas
Unknown Affiliation
Kouyos, Roger D.
Unknown Affiliation
Martinetti, Gladys
Unknown Affiliation
Martínez de Tejada, Begoῆa
Unknown Affiliation
Marzolini, Catia
Unknown Affiliation
Metzner, K. J.
Unknown Affiliation
Müller, Nicolas J.
Unknown Affiliation
Nadal, David
Unknown Affiliation
Nicca, Dunja
Unknown Affiliation
Pantaleo, Giuseppe P.
Unknown Affiliation
Rauch, Andri
Unknown Affiliation
Regenass, Stephan
Unknown Affiliation
Rudin, Christoph
Unknown Affiliation
Schmid, Patrick
Unknown Affiliation
Speck, Roberto F.
Unknown Affiliation
Stöckle, Marcel
Unknown Affiliation
Trkola, Alexandra
Unknown Affiliation
Vernazza, Pietro Luigi
Unknown Affiliation
Yerly, Sabine T.B.D.
Unknown Affiliation
Statistics
Citations: 5
Authors: 54
Affiliations: 10
Identifiers
Doi:
10.1093/ofid/ofw101
ISSN:
23288957
Research Areas
Genetics And Genomics
Infectious Diseases
Violence And Injury
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative