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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Therapeutic and diagnostic applications of nanoparticles
Current Drug Targets, Volume 12, No. 3, Year 2011
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Description
Nanoparticles are sphere-like biocompatible materials made of inert silica, metal or crystals of a few nanometers in size. They are emerging as a novel class of therapeutics for cancer treatment. Being more selective and specific toward their targets, nanoparticles have the ability to enhance the anticancer effects and to simultaneously reduce systemic toxicity compared with conventional therapeutics. Furthermore, they offer the potential to overcome drug resistance leading to higher intracellular drug accumulation. Nowadays, nanotechnologies are applied to molecular diagnostics and incorporated in cutting-edge molecular diagnostic methods, such as DNA and protein microarray biochips. Nanotechnologies enable diagnosis at the single-cell and single-molecule levels. Recent progress in cancer nanotechnology raises exciting opportunities for specific drug delivery. The purpose of this review is to give an overview about different types of nanoparticles and to summarize the latest results regarding their diagnostic and therapeutic applications in the clinic with more focus on cancer treatment. Furthermore, we discuss opportunities, limitations, and challenges faced by therapeutic nanoparticles. © 2011 Bentham Science Publishers Ltd.
Authors & Co-Authors
Youns, Mahmoud Moustafa
Germany, Mainz
Johannes Gutenberg-universität Mainz
Hoheisel, Jörg D.
Germany, Heidelberg
German Cancer Research Center
Efferth, Thomas H.
Germany, Mainz
Johannes Gutenberg-universität Mainz
Statistics
Citations: 99
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.2174/138945011794815257
ISSN:
13894501
Research Areas
Cancer
Genetics And Genomics
Health System And Policy