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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
MicroRNA-196b Regulates the Homeobox B7-Vascular Endothelial Growth Factor Axis in Cervical Cancer
PLoS ONE, Volume 8, No. 7, Article e67846, Year 2013
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Description
The down-regulation of microRNA-196b (miR-196b) has been reported, but its contribution to cervical cancer progression remains to be investigated. In this study, we first demonstrated that miR-196b down-regulation was significantly associated with worse disease-free survival (DFS) for cervical cancer patients treated with combined chemo-radiation. Secondly, using a tri-modal approach for target identification, we determined that homeobox-B7 (HOXB7) was a bona fide target for miR-196b, and in turn, vascular endothelial growth factor (VEGF) was a downstream transcript regulated by HOXB7. Reconstitution of miR-196b expression by transient transfection resulted in reduced cell growth, clonogenicity, migration and invasion in vitro, as well as reduced tumor angiogenesis and tumor cell proliferation in vivo. Concordantly, siRNA knockdown of HOXB7 or VEGF phenocopied the biological effects of miR-196b over-expression. Our findings have demonstrated that the miR-196b/HOXB7/VEGF pathway plays an important role in cervical cancer progression; hence targeting this pathway could be a promising therapeutic strategy for the future management of this disease. © 2013 How et al.
Authors & Co-Authors
How, Christine
Canada, Toronto
Princess Margaret Cancer Centre
Canada, Toronto
University of Toronto
Hui, Angela B.Y.
Canada, Toronto
Princess Margaret Cancer Centre
Alajez, Nehad M.
Saudi Arabia, Riyadh
College of Medicine
Shi, Wei
Canada, Toronto
Princess Margaret Cancer Centre
Boutros, Paul C.
Canada, Toronto
University of Toronto
Canada, Toronto
Ontario Institute for Cancer Research
Clarke, Blaise Alexander
Canada, Toronto
University Health Network University of Toronto
Yan, Rui
Canada, Toronto
Ontario Institute for Cancer Research
Pintilie, Melania
Canada, Toronto
Princess Margaret Cancer Centre
Fyles, A. W.
Canada, Toronto
Princess Margaret Cancer Centre
Canada, Toronto
University of Toronto
Hedley, David William
Canada, Toronto
Princess Margaret Cancer Centre
Canada, Toronto
University of Toronto
Hill, Richard P.
Canada, Toronto
Princess Margaret Cancer Centre
Canada, Toronto
University of Toronto
Milosevic, Michael F.
Canada, Toronto
Princess Margaret Cancer Centre
Canada, Toronto
University of Toronto
Liu, Fei Fei
Canada, Toronto
Princess Margaret Cancer Centre
Canada, Toronto
University of Toronto
Statistics
Citations: 65
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0067846
e-ISSN:
19326203
Research Areas
Cancer