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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Case report: Severe rift valley fever may present with a characteristic clinical syndrome
American Journal of Tropical Medicine and Hygiene, Volume 82, No. 3, Year 2010
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Description
Rift Valley fever (RVF) virus is an emerging pathogen that is transmitted in many regions of sub-Saharan Africa, parts of Egypt, and the Arabian peninsula. Outbreaks of RVF, like other diseases caused by hemorrhagic fever viruses, typically present in locations with very limited health resources, where initial diagnosis must be based only on history and physical examination. Although general signs and symptoms of human RVF have been documented, a specific clinical syndrome has not been described. In 2007, a Kenyan outbreak of RVF provided opportunity to assess acutely ill RVF patients and better delineate its presentation and clinical course. Our data reveal an identifiable clinical syndrome suggestive of severe RVF, characterized by fever, large-joint arthralgia, and gastrointestinal complaints and later followed by jaundice, right upper-quadrant pain, and delirium, often coinciding with hemorrhagic manifestations. Further characterization of a distinct RVF clinical syndrome will aid earlier detection of RVF outbreaks and should allow more rapid implementation of control. Copyright © 2010 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Kahlon, Summerpal S.
United States, Melbourne
Melbourne Internal Medicine Associates
Peter, Clarence J.
United States, Galveston
The University of Texas Medical Branch at Galveston
LeDuc, James W.
United States, Galveston
The University of Texas Medical Branch at Galveston
Muchiri, Eric M.
Kenya, Nairobi
Ministry of Public Health and Sanitation
Muiruri, Samuel K.
Kenya, Nairobi
Ministry of Public Health and Sanitation
Njenga, Moses Kariuki
United States, Atlanta
Centers for Disease Control and Prevention
Breiman, Robert F.
Kenya, Nairobi
Kenya Medical Research Institute
White, A. Clinton
United States, Galveston
University of Texas Medical Branch, School of Medicine
King, Charles Harding
United States, Cleveland
Case School of Medicine
Statistics
Citations: 68
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.4269/ajtmh.2010.09-0669
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Study Locations
Egypt