Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Epidemiologic and genotypic characteristics of rotavirus strains detected in children less than 5 years of age with gastroenteritis treated at 3 pediatric hospitals in Zimbabwe during 2008-2011
Pediatric Infectious Disease Journal, Volume 33, No. SUPPL. 1, Year 2014
Notification
URL copied to clipboard!
Description
BACKGROUND:: In anticipation of rotavirus vaccine introduction, the Zimbabwe Ministry of Health initiated rotavirus surveillance in 2008 to describe the rotavirus epidemiological trends and circulating genotypes among children <5 years of age. METHODS:: Active hospital-based surveillance for diarrhea was conducted at 3 sentinel sites from January 2008 to December 2011. Children aged <5 years, who presented with acute gastroenteritis as a primary illness and who were admitted to a hospital ward or treated at the emergency unit, were enrolled in the surveillance program and had a stool specimen collected and tested for rotavirus by enzyme immunoassay. Genotyping of a sample of positive specimens was performed using reverse-transcription polymerase chain reaction. RESULTS:: A total of 3728 faecal samples were collected and tested during the 4 year surveillance period and 1804 (48.5%) tested rotavirus positive. The highest prevalence of rotavirus diarrhea was found during the dry, cool season. Rotavirus positivity peaked in children 3-17 months of age with almost 80% of cases. Compared with rotavirus-negative cases, rotavirus-positive cases were more likely to be dehydrated (26% vs. 14%, P ≤ 0.001) and have vomiting (77% vs. 57%, P ≤ 0.001) and less likely to have fever (17% vs. 24%, P = 0.03). G9P[8] (43.3%), G1P[8] (11.8%), G2P[4] (8.7%), G2P[6] (8.7%) and G12P[6] (8.7%) were the most common genotypes detected. DISCUSSION:: Rotavirus causes a significant disease burden among children <5 years of age in Zimbabwe. This active surveillance system can serve as a platform to monitor the impact of rotavirus vaccine on disease burden following vaccine introduction. © 2013 Lippincott Williams and Wilkins.
Authors & Co-Authors
Mukaratirwa, Arnold
Zimbabwe, Harare
University of Zimbabwe
Zimbabwe
Zimbabwe Ministry of Health and Child Welfare
Berejena, Chipo
Zimbabwe, Harare
University of Zimbabwe
Nziramasanga, Pasipanodya
Zimbabwe, Harare
University of Zimbabwe
Shonhai, Annie
Zimbabwe, Harare
University of Zimbabwe
Zimbabwe
Zimbabwe Ministry of Health and Child Welfare
Mamvura, Tafadzwa S.
Zimbabwe, Harare
University of Zimbabwe
Chibukira, Paradzai
Zimbabwe, Harare
University of Zimbabwe
Mucheuki, Isabel
Zimbabwe, Harare
University of Zimbabwe
Mangwanya, Douglas
Zimbabwe
Zimbabwe Ministry of Health and Child Welfare
Kamupota, Mary
Zimbabwe
Zimbabwe Ministry of Health and Child Welfare
Manangazira, Portia
Zimbabwe
Zimbabwe Ministry of Health and Child Welfare
Tapfumaneyi, Christopher
Zimbabwe
Zimbabwe Ministry of Health and Child Welfare
Gerede, Regina
Zimbabwe
Zimbabwe Ministry of Health and Child Welfare
Munyoro, Mary
Zimbabwe, Harare
Who Regional Office for Africa
Mwenda, Jason Mathiu
Congo, Brazzaville
World Health Organization Regional Office for Africa Congo
Mphahlele, M. Jeffrey
South Africa, Sovenga
University of Limpopo
Seheri, Luyanda Mapaseka
South Africa, Sovenga
University of Limpopo
Peenze, Ina
South Africa, Sovenga
University of Limpopo
Gonah, Archebold N.
Zimbabwe, Chitungwiza
Chitungwiza Central Hospital
Maruta, Anna
Zimbabwe
Parirenyatwa Group of Hospitals
Tengende, Margaret B.
Zimbabwe, Harare
Harare Central Hospital
Statistics
Citations: 20
Authors: 20
Affiliations: 8
Identifiers
Doi:
10.1097/INF.0000000000000050
ISSN:
08913668
e-ISSN:
15320987
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Zimbabwe