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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children
Journal of Infectious Diseases, Volume 191, No. 8, Year 2005
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Description
Perennial and intense malaria transmission (holoendemic malaria) and Epstein-Barr virus (EBV) infection are 2 cofactors in the pathogenesis of endemic Burkitt lymphoma (eBL). In the present study, we compared EBV loads in children living in 2 regions of Kenya with differing malaria transmission intensities: Kisumu District, where malaria transmission is holoendemic, and Nandi District, where malaria transmission is sporadic. For comparison, blood samples were also obtained from US adults, Kenyan adults, and patients with eBL. Extraction of DNA from blood and quantification by polymerase chain reaction give an EBV load estimate that reflects the number of EBV-infected B cells. We observed a significant linear trend in mean EBV load, with the lowest EBV load detected in US adults and increasing EBV loads detected in Kenyan adults, Nandi children, Kisumu children, and patients with eBL, respectively. In addition, EBV loads were significantly higher in Kisumu children 1-4 years of age than in Nandi children of the same age. Our results support the hypothesis that repeated malaria infections in very young children modulate the persistence of EBV and increase the risk for the development of eBL. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Moormann, Ann M.
United States, Cleveland
Case School of Medicine
Chelimo, Kiprotich
Kenya, Nairobi
Kenya Medical Research Institute
Sumba, Odada P.
Kenya, Nairobi
Kenya Medical Research Institute
Lutzke, Mary L.
United States, Ann Arbor
University of Michigan, Ann Arbor
United States, Grand Rapids
Kent County Health Department
Ploutz-Snyder, Robert J.
United States, Syracuse
Suny Upstate Medical University
Newton, Duane W.
United States, Ann Arbor
University of Michigan, Ann Arbor
Kazura, James W.
United States, Cleveland
Case School of Medicine
Rochford, Rosemary A.
United States, Syracuse
Suny Upstate Medical University
Statistics
Citations: 201
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1086/428910
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Locations
Kenya