Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Red blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance
Nature Communications, Volume 12, No. 1, Article 1792, Year 2021
Notification
URL copied to clipboard!
Description
In both sickle cell disease and malaria, red blood cells (RBCs) are phagocytosed in the spleen, but receptor-ligand pairs mediating uptake have not been identified. Here, we report that patches of high mannose N-glycans (Man5-9GlcNAc2), expressed on diseased or oxidized RBC surfaces, bind the mannose receptor (CD206) on phagocytes to mediate clearance. We find that extravascular hemolysis in sickle cell disease correlates with high mannose glycan levels on RBCs. Furthermore, Plasmodium falciparum-infected RBCs expose surface mannose N-glycans, which occur at significantly higher levels on infected RBCs from sickle cell trait subjects compared to those lacking hemoglobin S. The glycans are associated with high molecular weight complexes and protease-resistant, lower molecular weight fragments containing spectrin. Recognition of surface N-linked high mannose glycans as a response to cellular stress is a molecular mechanism common to both the pathogenesis of sickle cell disease and resistance to severe malaria in sickle cell trait. © 2021, The Author(s).
Authors & Co-Authors
Cao, Huan
United Kingdom, Aberdeen
University of Aberdeen
Antonopoulos, Aristotelis
United Kingdom, London
Imperial College London
Brewin, John N.
United Kingdom, London
Ucl Cancer Institute
Erwig, Lars Peter
United Kingdom, Aberdeen
University of Aberdeen
Dell, Anne
United Kingdom, London
Ucl Cancer Institute
Brown, Gordon D.A.
United Kingdom, Aberdeen
University of Aberdeen
United Kingdom, London
Medical Research Council
Rees, David C.
United Kingdom, London
Ucl Cancer Institute
Haslam, Stuart M.
United Kingdom, London
Imperial College London
Rowe, Jane Alexandra
United Kingdom, Edinburgh
The University of Edinburgh
Barker, Robert Norman
United Kingdom, Aberdeen
University of Aberdeen
Vickers, Mark Adrian
United Kingdom, Aberdeen
University of Aberdeen
United Kingdom, Edinburgh
Scottish National Blood Transfusion Service
United Kingdom, Aberdeen
Aberdeen Royal Infirmary
Statistics
Citations: 15
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1038/s41467-021-21814-z
ISSN:
20411723
Research Areas
Infectious Diseases