Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
In vitro and in vivo characteristics of a thermogelling and bioadhesive delivery system intended for rectal administration of quinine in children
European Journal of Pharmaceutics and Biopharmaceutics, Volume 69, No. 1, Year 2008
Notification
URL copied to clipboard!
Description
The aim of this work was to improve the rectal bioavailability of quinine hydrochloride by designing thermosensitive and mucoadhesive gels intended for rectal delivery. The rheological and mucoadhesive properties of poloxamer 407 solutions have been modulated by addition of hydroxypropylmethycellulose (HPMC) and propanediol-1,2. In vitro release and rectal absorption of quinine have been highlighted by a dialysis dissolution testing method and by the determination of bioavailability of the different formulations in rabbits. Increasing the proportions of HPMC and poloxamer in the formulations resulted in a prolonged release of quinine. Indeed, compared to the DT 50% of a rectal solution and a simple HPMC gel (27 and 65 min, respectively) the DT 50% of thermosensitive ternary systems was increased and ranged between 80 and 138 min, depending on the system composition. The release rate depended strongly on the elasticity of the gels after thermogelation. The absolute rectal bioavailability of quinine determined in rabbits was significantly improved with these thermosensitive and adhesive systems. It increased from 62% for the rectal solution to 98% for a ternary system 16/0.5/30 (poloxamer (16%)/HPMC (0.5%)/propanediol-1,2 (30%)). As a result of combined bioadhesion and prolonged release of quinine in vivo, higher average values of MRT and tmax (9.1 ± 0.2 h and 30 min, respectively) were obtained compared to the rectal solution (6.9 ± 0.9 h and 15 min, respectively). Moreover, these formulations presented a very good rectal tolerance. Modulation by HPMC of the viscoelastic and mucoadhesive properties of poloxamer 407 thermogelling solutions allowed a prolonged release of quinine hydrochloride and an improvement of bioavailability in rabbit. © 2007 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Koffi, Armand Angely
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
France, Chatenay-malabry
Institut Galien Paris-saclay
Petit-Agnely, Florence
France, Chatenay-malabry
Institut Galien Paris-saclay
Besnard, Madeleine
France, Chatenay-malabry
Institut Galien Paris-saclay
Kablan Brou, J.
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Grossiord, Jean Louis
France, Chatenay-malabry
Institut Galien Paris-saclay
Ponchel, Gilles
France, Chatenay-malabry
Institut Galien Paris-saclay
Statistics
Citations: 43
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.ejpb.2007.09.017
ISSN:
09396411
Research Areas
Maternal And Child Health
Noncommunicable Diseases