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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic immunisation by liver stage antigen 3 protects chimpanzees against malaria despite low immune responses
PLoS ONE, Volume 3, No. 7, Article e2659, Year 2008
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Description
Background: The true interest of genetic immunisation might have been hastily underestimated based on overall immunogenicity data in humans and lack of parallelism with other, more classical immunisation methods. Principal Findings: Using malaria Liver Stage Antigen-3 (LSA-3), we report that genetic immunization induces in chimpanzees, the closest relative of humans, immune responses which are as scarce as those reported using other DNA vaccines in humans, but which nonetheless confer strong, sterile and reproducible protection. The pattern was consistent in 3/4 immunized apes against two high dose sporozoite challenges performed as late as 98 and 238 days post-immunization and by a heterologous strain. Conclusions: These results should, in our opinion, lead to a revisiting of the value of this unusual means of immunisation, using as a model a disease, malaria, in which virulent challenges of volunteers are ethically acceptable. © 2008 Daubersies et al.
Authors & Co-Authors
Daubersies, Pierre
France, Paris
Institut Pasteur, Paris
Ollomo, Benjamin
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Sauzet, Jean Pierre
France, Paris
Institut Pasteur, Paris
Brahimi, Karima
France, Paris
Institut Pasteur, Paris
Perlaza, Blanca Liliana
France, Paris
Institut Pasteur, Paris
Eling, Wijnand M.C.
Netherlands, Nijmegen
Radboud Universiteit
Moukana, Hubert
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Rouquet, Pierre
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
de Taisne, Charles
France, Lyon
Sanofi Pasteur sa
Druilhe, Pierre L.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 15
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0002659
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health