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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIV is an independent predictor of aortic stiffness
Journal of Cardiovascular Magnetic Resonance, Volume 16, No. 1, Article 57, Year 2014
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Description
Background: Patients with treated Human Immunodeficiency Virus-1 (HIV) infection are at increased risk of cardiovascular events. Traditionally much of this risk has been attributed to metabolic and anthropometric abnormalities associated with HIV, which are similar to the metabolic syndrome (MS), an established risk factor for cardiovascular mortality. It remains unclear whether treated HIV infection is itself associated with increased risk, via increase vascular stiffness. Methods. 226 subjects (90 with HIV) were divided into 4 groups based on HIV and MS status: 1) HIV-ve/MS-ve, 2) HIV-ve/MS + ve, 3) HIV + ve/MS-ve and 4)HIV + ve/MS + ve. CMR was used to determine aortic pulse wave velocity (PWV) and regional aortic distensibility (AD). Results: PWV was 11% higher and regional AD up to 14% lower in the HIV + ve/MS-ve group when compared to HIV-ve/MS-ve (p < 0.01 all analyses). PWV and AD in the HIV + ve/MS-ve group was similar to that observed in the HIV-ve/MS + ve group (p > 0.99 all analyses). The HIV + ve/MS + ve group had 32% higher PWV and 30-34% lower AD than the HIV-ve/MS-ve group (all p < 0.001), and 19% higher PWV and up to 31% lower AD than HIV + ve/MS-ve subjects (all p < 0.05). On multivariable regression, age, systolic blood pressure and treated HIV infection were all independent predictors of both PWV and regional AD. Conclusion: Across multiple measures, treated HIV infection is associated with increased aortic stiffness and is also an independent predictor of both PWV and regional AD. The magnitude of the effect of treated HIV and MS are similar, with additive detrimental effects on central vascular elasticity. © 2014 Rider et al.; licensee BioMed Central.
Authors & Co-Authors
Rider, Oliver J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
John Radcliffe Hospital
Ntusi, Ntobeko A.B.
United Kingdom, Oxford
John Radcliffe Hospital
Wainwright, Emma
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Clutton, Genevieve T.
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Hancock, Gemma
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Banerjee, Rajarshi
United Kingdom, Oxford
University of Oxford
Clarke, Kieran J.
United Kingdom, Oxford
University of Oxford
Neubauer, Stefan
United Kingdom, Oxford
John Radcliffe Hospital
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Dorrell, Lucy
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Holloway, Cameron J.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
John Radcliffe Hospital
Australia, Sydney
St. Vincent's Hospital Sydney
Statistics
Citations: 28
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1186/s12968-014-0057-1
ISSN:
10976647
Research Areas
Infectious Diseases
Noncommunicable Diseases