Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Tracer kinetic model selection for dynamic contrast-enhanced magnetic resonance imaging of locally advanced cervical cancer
Acta Oncologica, Volume 53, No. 8, Year 2014
Notification
URL copied to clipboard!
Description
Background. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) offers a unique capability to probe tumour microvasculature. Different analysis of the acquired data will possibly lead to different conclusions. Therefore, the objective of this study was to investigate under which conditions the Tofts (TM), extended Tofts (ETM), compartmental tissue uptake model (C-TU) and 2-compartment exchange model (2CXM) were the optimal tracer kinetic models (TKMs) for the analysis of DCE-MRI in patients with cervical cancer. Material and methods. Ten patients with locally advanced cervical cancer (FIGO: IIA/IIB/IIIB/IVA-1/5/3/1) underwent DCE-MRI prior to radiotherapy. From the two-parameter TM it was possible to extract the forward volume transfer constant (Ktrans) and the extracellular-extravascular volume fraction (ve). From the three-parameter ETM, additionally the plasma volume fraction (vp) could be extracted. From the three-parameter C-TU it was possible to extract information about the blood flow (Fp), permeability-surface area product (PS) and vp. Finally, the four-parameter 2CXM extended the C-TU to include ve. For each voxel, corrected Akaike information criterion (AICc) values were calculated, taking into account both the goodness-of-fit and the number of model parameters. The optimal model was defined as the model with the lowest AICc. Results. All four TKMs were the optimal model in different contiguous regions of the cervical tumours. For the 24 999 analysed voxels, the TM was optimal in 17.0%, the ETM was optimal in 2.2%, the C-TU in 23.4% and the 2CXM was optimal in 57.3%. Throughout the tumour, a high correlation was found between K trans(TM) and Fp(2CXM), ρ = 0.91. Conclusion. The 2CXM was most often optimal in describing the contrast agent enhancement of pre-treatment cervical cancers, although this model broke down in a subset of the tumour voxels where overfitting resulted in non-physiological parameter estimates. Due to the possible overfitting of the 2CXM, the C-TU was found more robust and when 2CXM was excluded from comparison the C-TU was the preferred model. © 2014 Informa Healthcare.
Authors & Co-Authors
Kallehauge, J. F.
Denmark, Aarhus
Aarhus Universitetshospital
Tanderup, Kari
Denmark, Aarhus
Aarhus Universitetshospital
United States, St. Louis
Washington University School of Medicine in St. Louis
Duan, Chong
United States, St. Louis
Washington University in St. Louis
Haack, Søren
Denmark, Aarhus
Aarhus Universitetshospital
Pedersen, Erik Morre
Denmark, Aarhus
Aarhus Universitetshospital
Lindegaard, Jacob Christian
Denmark, Aarhus
Aarhus Universitetshospital
Fokdal, Lars Ulrik
Denmark, Aarhus
Aarhus Universitetshospital
Mohamed, Sandy Mohamed Ismail
Denmark, Aarhus
Aarhus Universitetshospital
Egypt, Giza
Cairo University
Nielsen, Tommy Kjærgaard
Denmark, Aarhus
Aarhus Universitet
Statistics
Citations: 25
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.3109/0284186X.2014.937879
ISSN:
0284186X
e-ISSN:
1651226X
Research Areas
Cancer
Health System And Policy