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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Malaria prophylaxis and the reduction of anemia at childbirth
International Journal of Gynecology and Obstetrics, Volume 74, No. 2, Year 2001
Notification
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Description
Objectives: To assess the effect of introducing chloroquine prophylaxis during pregnancy on prevalence of anemia (<10.9 g/dl) at childbirth and perinatal outcome. Methods: Observational study in a rural district hospital in Ghana, which compared 2803 women who received chloroquine prophylaxis during pregnancy with 3084 historical controls, who had not received prophylaxis during pregnancy. Main outcome measures were hemoglobin level at childbirth, perinatal mortality and birth weight. Results: Mean hemoglobin level before childbirth increased from 10.7 g/dl (S.D.=1.0 g/dl) to 11.0 g/dl (S.D.=0.9 g/dl). Prevalence of anemia decreased from 29.4 to 13.3% (OR=0.4 and 95% CI=0.3-0.4). Prevalence of moderately severe anemia (<9.0 g/dl) decreased from 4.4 to 3.3% (OR=0.7, 95% CI=0.6-0.97). Perinatal mortality and low birth weight (<2500 g) remained unchanged. Conclusions: Routine chloroquine prophylaxis in pregnancy is useful in reducing anemia at childbirth in malaria-endemic regions. Fetal outcome did not improve with chloroquine prophylaxis in this study. Copyright © 2001 International Federation of Gynecology and Obstetrics. All rights reserved.
Authors & Co-Authors
Geelhoed, Diederike W.
Ghana
Holy Family Hospital
Visser, Lucia E.
Ghana
Holy Family Hospital
Addae, V.
Ghana
Holy Family Hospital
Asare, K.
Ghana
Regional Health Administration (brong Ahafo)
Schagen Van Leeuwen, Jules H.
Netherlands, Nieuwegein
St. Antonius Ziekenhuis
van Roosmalen, Jos J.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Statistics
Citations: 12
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1016/S0020-7292(01)00419-2
ISSN:
00207292
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Ghana
Participants Gender
Female