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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The enigmatic mechanisms by which Plasmodium vivax infects Duffy-negative individuals
PLoS Pathogens, Volume 16, No. 2, Article e1008258, Year 2020
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Description
The absence of the Duffy protein at the surface of erythrocytes was considered for decades to confer full protection against Plasmodium vivax as this blood group is the receptor for the key parasite ligand P. vivax Duffy binding protein (PvDBP). However, it is now clear that the parasite is able to break through this protection and induce clinical malaria in Duffy-negative people, although the underlying mechanisms are still not understood. Here, we briefly review the evidence of Duffy-negative infections by P. vivax and summarize the current hypothesis at the basis of this invasion process. We discuss those in the perspective of malaria-elimination challenges, notably in African countries. © 2020 Popovici et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Authors & Co-Authors
Popovici, Jean
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Roesch, Camille
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Rougeron, Virginie
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Statistics
Citations: 23
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1371/journal.ppat.1008258
ISSN:
15537366
Research Areas
Health System And Policy
Infectious Diseases