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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Response to antiretroviral therapy (ART): Comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women
BMC Infectious Diseases, Volume 14, No. 1, Article 127, Year 2014
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Description
Background: Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started.Methods: Data were obtained by linking two UK studies: the UK Collaborative HIV Cohort (UK CHIC) study and the National Study of HIV in Pregnancy and Childhood (NSHPC). Treatment responses were assessed for 2028 women initiating ART at least one year after HIV-diagnosis. Outcomes were compared using logistic regression, proportional hazards regression or linear regression.Results: In adjusted analyses, ART-naïve (n = 1937) and ZDVm-experienced (n = 91) women had similar increases in CD4 count and a similar proportion achieving virological suppression; both groups had a low risk of AIDS.Conclusions: In this setting, antenatal ZDVm exposure did not adversely impact on outcomes once ART was initiated for the woman's health. © 2014 Huntington et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Huntington, Susie E.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
United Kingdom, London
University College London
United Kingdom, London
Royal Free London Nhs Foundation Trust
Thorne, Claire N.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Anderson, Jane
United Kingdom, London
Homerton University Hospital Nhs Foundation Trust
Newell, Marie Louise
United Kingdom, Southampton
University of Southampton
Taylor, Graham P.
United Kingdom, London
Imperial College London
Morris, Lynn G.
United Kingdom, London
University College London
United Kingdom, London
Public Health England
Hill, Teresa
United Kingdom, London
University College London
United Kingdom, London
Royal Free London Nhs Foundation Trust
Tookey, Pat A.
United Kingdom, London
Ucl Great Ormond Street Institute of Child Health
Sabin, Caroline Anne
United Kingdom, London
University College London
United Kingdom, London
Royal Free London Nhs Foundation Trust
Ainsworth, Jonathan G.
United Kingdom, London
North Middlesex University Hospital Nhs Trust
Babiker, Abdel G.A.G.
United Kingdom, London
Medical Research Council
Chadwick, David Robert
United Kingdom, Middlesbrough
South Tees Hospitals Nhs Foundation Trust
Delpech, Valerie C.
United Kingdom, London
Public Health England
Dunn, David T.
United Kingdom, London
Medical Research Council
Fisher, Martin J.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Jose, Sophie
United Kingdom, London
University College London
United Kingdom, London
Royal Free London Nhs Foundation Trust
Gazzard, Brian George L.
United Kingdom, London
Chelsea and Westminster Hospital Nhs Foundation Trust
Gilson, Richard John Cary
United Kingdom, London
University College London
Hay, Phillip E.
United Kingdom, London
St George's University Hospitals Nhs Foundation Trust
Gompels, Mark M.
United Kingdom, Bristol
North Bristol Nhs Trust
Johnson, Margaret A.
United Kingdom, London
Royal Free London Nhs Foundation Trust
Kegg, Stephen
United Kingdom, London
South London and Maudsley Nhs Foundation Trust
Leen, Clifford L.S.
United Kingdom, Edinburgh
Nhs Lothian
Nelson, Mark Richard
United Kingdom, London
Chelsea and Westminster Hospital Nhs Foundation Trust
Orkin, Chloë M.
United Kingdom, London
Barts Health Nhs Trust
Palfreeman, Adrian J.
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Phillips, Andrew N.
United Kingdom, London
University College London
United Kingdom, London
Royal Free London Nhs Foundation Trust
Post, Frank A.
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Sachikonye, Memory
United Kingdom, London
Uk Community Advisory Board
Schwenk, Achim
United Kingdom, London
North Middlesex University Hospital Nhs Trust
Walsh, John Christopher
United Kingdom, London
Imperial College Healthcare Nhs Trust
Thornton, Alicia Claire
United Kingdom, London
University College London
United Kingdom, London
Royal Free London Nhs Foundation Trust
Glabay, Adam J.
United Kingdom, London
Medical Research Council
Garrett, Nigel J.
United Kingdom, London
Barts Health Nhs Trust
Lynch, Janet
United Kingdom, London
Barts Health Nhs Trust
Hand, James
United Kingdom, London
Barts Health Nhs Trust
Perry, Nicky
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Tilbury, Stuart
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Youssef, Elaney
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Churchill, Duncan R.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Waxman, Matthew
United Kingdom, London
Chelsea and Westminster Hospital Nhs Foundation Trust
Asboe, David
United Kingdom, London
Chelsea and Westminster Hospital Nhs Foundation Trust
Mandalia, Sundhiya
United Kingdom, London
Chelsea and Westminster Hospital Nhs Foundation Trust
Munshi, Sajid
United Kingdom, London
Homerton University Hospital Nhs Foundation Trust
Awosika, Damilola D.
United Kingdom, London
Homerton University Hospital Nhs Foundation Trust
Korat, Hardik
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Taylor, Christopher B.
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Gleisner, Zachary
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Ibrahim, Fowzia A.
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Campbell, Lucy J.
United Kingdom, London
King's College Hospital Nhs Foundation Trust
Baillie, Kirsty
United Kingdom, Middlesbrough
South Tees Hospitals Nhs Foundation Trust
Brima, Nataliya
United Kingdom, London
University College London
Williams, Ian G.
United Kingdom, London
University College London
Miller, Sheila
United Kingdom, London
North Middlesex University Hospital Nhs Trust
Wood, Christopher W.
United Kingdom, London
North Middlesex University Hospital Nhs Trust
Youle, Mike S.
United Kingdom, London
Royal Free London Nhs Foundation Trust
Lampe, Fiona C.
United Kingdom, London
Royal Free London Nhs Foundation Trust
Smith, Colette Joanne
United Kingdom, London
Royal Free London Nhs Foundation Trust
Grabowska, Helen
United Kingdom, London
Royal Free London Nhs Foundation Trust
Chaloner, Clinton
United Kingdom, London
Royal Free London Nhs Foundation Trust
Weber, Jonathan N.
United Kingdom, London
Imperial College Healthcare Nhs Trust
Ramzan, Farhan
United Kingdom, London
Imperial College Healthcare Nhs Trust
Carder, Mark
United Kingdom, London
Imperial College Healthcare Nhs Trust
Wilson, Alan C.
United Kingdom, Edinburgh
Nhs Lothian
Allan, Sue
United Kingdom, Bristol
North Bristol Nhs Trust
Fox, Lynn
United Kingdom, Leicester
University Hospitals of Leicester Nhs Trust
Main, Paul
United Kingdom, London
South London and Maudsley Nhs Foundation Trust
Dhillon, Mandip
United Kingdom, London
St George's University Hospitals Nhs Foundation Trust
Statistics
Citations: 2
Authors: 68
Affiliations: 21
Identifiers
Doi:
10.1186/1471-2334-14-127
ISSN:
14712334
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female