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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Coxiella burnetii in humans and ticks in rural Senegal
PLoS Neglected Tropical Diseases, Volume 4, No. 4, Year 2010
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Description
Background: Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts. Methodology/Principal Findings: We investigated Q fever in rural Senegal. Human samples (e.g., sera, saliva, breast milk, feces) were screened in the generally healthy population of two villages of the Sine-Saloum region. Ticks were collected in four regions. Seroprevalence was studied by immunofluorescence, and all other samples were tested by two qPCR systems for detection of C. burnetii. Positive samples were genotyped (multispacer typing) by amplification and sequencing of three spacers. Strains were isolated by cell culture. We found that the seroprevalence may be as high as 24.5% (59 of 238 studied) in Dielmo village. We identified spontaneous excretion of C. burnetii by humans through faeces and milk. Hard and soft ticks (8 species) were infected in 0-37.6%. We identified three genotypes of C. burnetii. The previously identified genotype 6 was the most common in ticks in all studied regions and the only one found in human samples. Three strains of genotype 6 of C. burnetii were also recovered from soft tick Ornithodoros sonrai. Two other genotypes found in ticks, 35 and 36, were identified for the first time. Conclusions/Significance: Q fever should be considered a significant public health threat in Senegal. Humans, similar to other mammals, may continuously excrete C. burnetii. © 2010 Mediannikov et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2850317/bin/pntd.0000654.s001.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2850317/bin/pntd.0000654.s002.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2850317/bin/pntd.0000654.s003.doc
Authors & Co-Authors
Mediannikov, Oleg Y.
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Fénollar, Florence
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Socolovschi, Cristina
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Diatta, Georges
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Basséne, Hubert
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Molez, Jean François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Sokhna, Cheikh Sadibou
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Trape, Jean François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Raoult, Didier A.
France, Marseille
Unité de Recherche Sur Les Maladies Infectieuses et Tropicales Emergentes
Statistics
Citations: 198
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1371/journal.pntd.0000654
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Senegal