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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The genome of the blood fluke Schistosoma mansoni
Nature, Volume 460, No. 7253, Year 2009
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Description
Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new families of micro-exon genes that undergo frequent alternative splicing. As the first sequenced flatworm, and a representative of the Lophotrochozoa, it offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and the development of tissues into organs. Our analysis has been informed by the need to find new drug targets. The deficits in lipid metabolism that make schistosomes dependent on the host are revealed, and the identification of membrane receptors, ion channels and more than 300 proteases provide new insights into the biology of the life cycle and new targets. Bioinformatics approaches have identified metabolic chokepoints, and a chemogenomic screen has pinpointed schistosome proteins for which existing drugs may be active. The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease. © 2009 Macmillan Publishers Limited. All rights reserved.
Authors & Co-Authors
Berriman, Matthew
United Kingdom, Hinxton
Wellcome Sanger Institute
Haas, Brian J.
United States, Rockville
J. Craig Venter Institute
United States, Cambridge
Broad Institute
LoVerde, Philip T.
United States, San Antonio
The University of Texas at San Antonio
Wilson, R. Alan
United Kingdom, York
University of York
Cerqueira, Gustavo Coutinho
United States, College Park
University of Maryland, College Park
Mashiyama, Susan T.
United States, San Francisco
University of California, San Francisco
Al-Lazikani, Bissan
United Kingdom, London
The Institute of Cancer Research
Aslett, Martin A.
United Kingdom, Hinxton
Wellcome Sanger Institute
Caffrey, Conor Robert
United States, San Francisco
University of California, San Francisco
Coghlan, Avril
Ireland, Cork
University College Cork
Coulson, Richard M.R.
United Kingdom, Hinxton
Embl’s European Bioinformatics Institute
Day, Tim A.
United States, Ames
Iowa State University
Delcher, Arthur L.
United States, College Park
University of Maryland, College Park
Djikeng, Appolinaire
United States, Rockville
J. Craig Venter Institute
Gamble, John A.
United Kingdom, Hinxton
Wellcome Sanger Institute
Ghedin, Elodie
United States, Rockville
J. Craig Venter Institute
United States, Pittsburgh
University of Pittsburgh
Hertz-Fowler, Christiane
United Kingdom, Hinxton
Wellcome Sanger Institute
Hirai, Hirohisha
Japan, Kyoto
Kyoto University
Hirai, Yuriko
Japan, Kyoto
Kyoto University
Ivens, Alasdair C.
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Edinburgh
Fios Genomics Ltd.
Johnston, David A.
United Kingdom, London
The Natural History Museum, London
United Kingdom, Southampton
University of Southampton, Faculty of Medicine
Lacerda, Daniela Rodrigues
United States, Rockville
J. Craig Venter Institute
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Oliveira, Guilherme Corrêa De
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Parkhill, Julian
United Kingdom, Hinxton
Wellcome Sanger Institute
Pertea, Mihaela
United States, College Park
University of Maryland, College Park
Pierce, Raymond John
France, Lille
Institut Pasteur de Lille
Protasio, Anna V.
United Kingdom, Hinxton
Wellcome Sanger Institute
Quail, Michael A.
United Kingdom, Hinxton
Wellcome Sanger Institute
Rajandream, Marie Adèle
United Kingdom, Hinxton
Wellcome Sanger Institute
Rogers, Jane
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Norwich
John Innes Centre
Sajid, Mohammed
United States, San Francisco
University of California, San Francisco
Netherlands, Leiden
Leids Universitair Medisch Centrum
Salzberg, Steven L.
United States, College Park
University of Maryland, College Park
Stanke, Mario
Germany, Gottingen
Georg-august-universität Göttingen
Tivey, Adrian R.N.
United Kingdom, Hinxton
Wellcome Sanger Institute
White, Owen R.
United States, Rockville
J. Craig Venter Institute
United States, Baltimore
University of Maryland School of Medicine
Williams, David Lee
United States, Chicago
Illinois State University
United States, Chicago
Rush University Medical Center
Wortman, Jennifer Russo
United States, Rockville
J. Craig Venter Institute
United States, Baltimore
University of Maryland School of Medicine
Zamanian, Mostafa
United States, Ames
Iowa State University
Zerlotini, Adhemar
United Kingdom, London
The Institute of Cancer Research
Fraser, Claire M.
United States, Rockville
J. Craig Venter Institute
United States, Baltimore
University of Maryland School of Medicine
Barrell, Barclay G.
United Kingdom, Hinxton
Wellcome Sanger Institute
El-Sayed, Najib M.A.
United States, Rockville
J. Craig Venter Institute
United States, College Park
University of Maryland, College Park
Statistics
Citations: 866
Authors: 42
Affiliations: 27
Identifiers
Doi:
10.1038/nature08160
ISSN:
14764687
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Noncommunicable Diseases