Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Plasmodium falciparum: DNA probe diagnosis of malaria in Kenya
Experimental Parasitology, Volume 69, No. 2, Year 1989
Notification
URL copied to clipboard!
Description
We previously reported isolation of a DNA probe which specifically recognizes Plasmodium falciparum and developed a simple method for its use. The sensitivity and specificity of this DNA probe method have now been extensively field tested in comparison with those of conventional microscopic examination of blood films in two separate studies in Malindi, Kenya, involving a total of 1179 patients. In the second study, which used improved techniques, sensitivity of the DNA probe was 89% when compared to microscopy. We conclude that the DNA probe method compares favorably with conventional microscopy in detecting parasite densities as low as 25 parasites per microliter of blood. A significant advantage of the DNA probe method is that it utilizes a standardized procedure which can simultaneously and reproducibly analyze a large number of samples without opportunity for significant reader bias. © 1989.
Authors & Co-Authors
Barker, Robert H.
United States, Boston
Harvard T.h. Chan School of Public Health
Brandling-Bennett, A. David
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Atlanta
National Center for Infectious Diseases
Koech, David Kiprotich
Kenya, Nairobi
Kenya Medical Research Institute
Mugambi, Mutuma
Kenya, Nairobi
Kenya Medical Research Institute
Khan, Baldip K.
Kenya, Nairobi
Kenya Medical Research Institute
David, Roberta
United States, Boston
Harvard T.h. Chan School of Public Health
David, John R.
United States, Boston
Harvard T.h. Chan School of Public Health
Wirth, Dyann F.
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 13
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/0014-4894(89)90069-6
ISSN:
00144894
e-ISSN:
10902449
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Kenya