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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemical engineering
ZnO nanoparticles induce oxidative stress in cloudman S91 melanoma cancer cells
Journal of Biomedical Nanotechnology, Volume 9, No. 3, Year 2013
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Description
The well-crystallized ZnO nanoparticles were synthesized by a simple and facile soft chemical approach, and their induction of oxidative stress in Cloudman S91 melanoma cancer cells was studied. The ZnO nanoparticles were characterized for their morphology, structure, and optical properties. The ZnO nanoparticles with the average size of ~10 nm grew in high density, possessing wurtzite hexagonal phase. To study the induction of oxidative stress by ZnO nanoparticles in Cloudman S91 melanoma cancer cells, various doses of ZnO nanoparticles were treated with melanoma cancer cells for 24 h of incubation at 37 °C. The viability of the cells was analyzed with MTT method, whereas the morphology of the cells was observed via confocal laser scanning microscopy (CLSM), which revealed that when the time interval was increased, the number of cells decreased. The apoptosis-correlated, intracellular production of reactive oxygen species (ROS) was also measured with melanoma cancer cells with varying ZnO nanoparticle doses. Copyright © 2013 American Scientific Publishers All rights reserved.
Authors & Co-Authors
Wahab, Rizwan
South Korea, Jeonju
Jeonbuk National University
Saudi Arabia, Riyadh
College of Sciences
Dwivedi, Sourabh
Saudi Arabia, Riyadh
College of Sciences
Umar, Ahmad S.
Saudi Arabia, Najran
Najran University
Singh, Surya
United Kingdom, London
Imperial College London
Hwang, Inho
South Korea, Jeonju
Jeonbuk National University
Shin, Hyung-shik
South Korea, Jeonju
Jeonbuk National University
Musarrat, Javed
Saudi Arabia, Riyadh
College of Sciences
India, Aligarh
Aligarh Muslim University
Al-Khedhairy, Abdulaziz Ali A.
Saudi Arabia, Riyadh
College of Sciences
Kim, Young Soon
South Korea, Jeonju
Jeonbuk National University
Statistics
Citations: 91
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1166/jbn.2013.1593
ISSN:
15507033
e-ISSN:
15507041
Research Areas
Cancer