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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
Nature Genetics, Volume 44, No. 8, Year 2012
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Description
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital-or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10-8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ∼110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function. © 2012 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Okada, Yukinori
Unknown Affiliation
Sim, Xueling
Unknown Affiliation
Wu, Jeryuarn
Unknown Affiliation
Gu, Dongfeng
Unknown Affiliation
Takeuchi, Fumihiko
Unknown Affiliation
Takahashi, Atsushi
Unknown Affiliation
Tsunoda, Tatsuhiko
Unknown Affiliation
Wong, Tienyin
Unknown Affiliation
Liu, Jianjun
Unknown Affiliation
Young, Terri L.
Unknown Affiliation
Aung, Tin
Unknown Affiliation
Seielstad, Mark
Unknown Affiliation
Teo, Yik Ying
Unknown Affiliation
Han, Bokghee
Unknown Affiliation
Chen, Chien Hsiun
Unknown Affiliation
Tsai, Fuujen Jenn
Unknown Affiliation
Chang, Liching
Unknown Affiliation
Mei, Hao
Unknown Affiliation
Rao, Dabeeru C.
Unknown Affiliation
Chen, Shufeng
Unknown Affiliation
Yamamoto, Kazuhiko
Unknown Affiliation
Kubo, Michiaki
Unknown Affiliation
Nakamura, Yusuke
Unknown Affiliation
Kato, Norihiro
Unknown Affiliation
He, Jiang Y.
Unknown Affiliation
Chen, Yuantsong Tsong
Unknown Affiliation
Tai, E. Shyong
Unknown Affiliation
Tanaka, Toshihiro
Unknown Affiliation
Lord, Graham M.
Unknown Affiliation
van der Harst, Pim
Unknown Affiliation
Lawlor, Debbie A.
Unknown Affiliation
Sehmi, Joban S.
Unknown Affiliation
Gale, Daniel Philip
Unknown Affiliation
Wass, Mark Nicholas
Unknown Affiliation
Bakker, Stephan J.L.
Unknown Affiliation
Beckmann, Jacques S.
Unknown Affiliation
Brown, Morris J.
Unknown Affiliation
Caulfield, Mark J.
Unknown Affiliation
Connell, John M.C.
Unknown Affiliation
Smith, George D.
Unknown Affiliation
Devuyst, Olivier
Unknown Affiliation
Dikkeschei, Lambert D.
Unknown Affiliation
Dominiczak, Anna F.D.
Unknown Affiliation
Ebrahim, Shah B.J.
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Eggermann, Thomas
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Farrall, Martin
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Ferrucci, Luigi G.
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Floege, Jürgen
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Forouhi, Nita G.
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Gansevoort, Ron T.
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Hedblad, Bo
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Hyppönen, Elina
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Loos, Ruth J.F.
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Luan, Jian'fan N.An
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Melander, Olle
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Munroe, Patricia B.
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Peltonen-Palotie, Leena Johanna
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Penninx, Brenda W. J. H.
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Prokopenko, Inga I.
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Roderick, Paul J.
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Samani, Nilesh J.
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Sanna, Serena
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Schalling, Martin
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Schlessinger, David
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Sjögren, Marketa
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Smit, Johannes Hendrikus
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Soranzo, Nicole
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Spector, Tim David
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Vollenweider, Peter K.
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Waterworth, Dawn M.
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Zerres, Klaus P.
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Wareham, Nicholas J.
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McCarthy, Mark I.
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J̈arvelin, Märjo Riitta R.
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Mooser, Vincent E.
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Abecasis, Gonçalo R.
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Lightstone, Liz
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Scott, James M.
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Navis, Gerjan J.
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Elliott, Paul E.
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Kooner, Jaspal Singh
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Pattaro, Cristian
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Böger, Carsten Alexander
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Fuchsberger, Christian
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Olden, Matthias
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Glazer, Nicole L.
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Smith, Albert Vernon
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O'Connell, Jeffrey R.
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Isaacs, Aaron J.
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Hwang, Shihjen
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Johnson, Andrew Danner
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Dehghan, Abbas
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Teumer, Alexander
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Paré, Guillaume
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Lohman, Kurt K.
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Cornelis, Marylin C.
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Kronenberg, Florian
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Aspelund, Thor
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Eiríksdóttir, Gudný H.
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Harris, Tamara B.
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Rampersaud, Evadnie
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Arking, Dan E.
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Boerwinkle, Eric A.
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Singleton, Andrew B.
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de Boer, Ian H.
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Haritunians, Talin
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Psaty, Bruce M.
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Zillikens, Maria Carola
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Oostra, Ben A.
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Feitosa, Mary Furlan
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Province, Michael A.
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de Andrade, Mariza A.
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Turner, Stephen T.
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Schillert, Arne
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Ziegler, Andreas E.
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Wild, Philipp S.
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Schnabel, Renate B.
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Münzel, Tomas F.
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Leak, Tennille S.
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Illig, Thomas
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Meisinger, Christa
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Wichmann, Heinz Erich
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Koenig, Wolfgang F.
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Zgaga, Lina
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Zemunik, T.
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Minelli, Cosetta
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Johansson, Anna C.V.
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Ellinghaus, David
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Schreiber, Stefan W.
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Aulchenko, Yurii S.
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Felix, Janine Frédérique
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Uitterlinden, André G.
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Hofman, Albert
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Nitsch, Dorothea D.M.
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Kloss-Brandstätter, Anita
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Kollerits, Barbara
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Kedenko, Lyudmyla
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Mägi, Reedik
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Kovács, Péter F.
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Endlich, Karlhans
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Völzke, Henry
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Völker, Uwe
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Polašek, Ozren
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Ridker, Paul M.
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Kardia, Sharon L.R.
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Blankenberg, Stefan S.
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Franke, Andre
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Paulweber, Bernhard
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Gudnason, V. G.
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Shuldiner, Alan R.
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Coresh, Josef
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Shlipak, Michael G.
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van Duijn, Cornelia M.
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Krämer, Bernhard Karl
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Rudan, Igor
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Witteman, Jacqueline C.M.
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Pramstaller, Peter P.
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Schmidt, Helena
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Montgomery, Grant W.
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Salomaa, Veikko V.
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Shin, So-youn
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Sala, Cinzia Felicita
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Kähönen, Mika A.P.
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Viikari, Jorma S.A.
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Hengstenberg, Christian
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Meschia, James Frederick
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Nalls, Mike A.
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Singleton, Andrew B.
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Kamatani, Naoyuki
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Zeller, Tanja
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Burnier, Michel
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Attia, John Richard
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Klopp, Norman
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Probst-Hensch, Nicole M.
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Völzke, Henry
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Schmidt, Reinhold T.
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Whitfield, John B.
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Siscovick, David S.
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Metspalu, Andres H.
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Wolffenbuttel, Bruce H.R.
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Dunlop, Malcolm G.
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Statistics
Citations: 227
Authors: 306
Identifiers
Doi:
10.1038/ng.2352
ISSN:
10614036
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review