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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antibody‐dependent cellular cytotoxicity against epstein‐barr virus‐associated antigens in african patients with nasopharyngeal carcinoma
International Journal of Cancer, Volume 22, No. 2, Year 1978
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Description
Antibody‐dependent cellular cytotoxicity (ADCC) was performed on serum samples from African patients with nasopharyngeal carcinoma (NPC) to determine whether antibody titers determined by this assay might be of prognostic value in this disease. The serum donors were divided into two groups: (1) those individuals who died within 2 years following diagnosis of NPC; and (2) individuals who responded well to therapy and survived for more than 2 years following diagnosis. The ADCC GMT for the survivor group was significantly higher than the GMT for non‐survivors (5,410 versus 615). Interestingly, there were a number of discordant sera in the non‐survivor group that had very low ADCC titers (<240) at diagnosis in the presence of high VCA titers. When ADCC titers were compared with anti‐EA or IgA antibody titers to VCA, a statistically significant inverse correlation was noted. These data suggest that ADCC titers might be of prognostic importance in African NPC. Copyright © 1978 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Pearson, Gary R.
United States, Rochester
Mayo Clinic
Kenya, Nairobi
Kenyatta National Hospital
Sweden, Stockholm
Radiumhemmet
Sweden, Stockholm
Karolinska Institutet
Johansson, Bo C.
United States, Rochester
Mayo Clinic
Kenya, Nairobi
Kenyatta National Hospital
Sweden, Stockholm
Radiumhemmet
Sweden, Stockholm
Karolinska Institutet
Klein, George O.
United States, Rochester
Mayo Clinic
Kenya, Nairobi
Kenyatta National Hospital
Sweden, Stockholm
Radiumhemmet
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 70
Authors: 3
Affiliations: 4
Identifiers
Doi:
10.1002/ijc.2910220203
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Cancer