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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnostic performance of amyloid A protein quantification in fat tissue of patients with clinical AA amyloidosis
Amyloid, Volume 14, No. 2, Year 2007
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Description
Objective. Amyloid A protein quantification in fat tissue is a new immunochemical method for detecting AA amyloidosis, a rare but serious disease. The objective was to assess diagnostic performance in clinical AA amyloidosis. Methods. Abdominal subcutaneous fat tissue of patients with AA amyloidosis was studied at the start of an international clinical trial with eprodisate (NC-503; 1,3-propanedisulfonate; Kiacta™), an antiamyloid compound. All patients had renal findings, i.e. proteinuria (≥1 g/day) or reduced creatinine clearance (20 - 60 ml/min). Controls were patients with other types of amyloidosis and arthritic patients without amyloidosis. Amyloid A protein was quantified by ELISA using monoclonal antihuman serum amyloid A antibodies. Congo red stained slides were scored by light microscopy in a semiquantitative way (0 to 4+). Results. Ample fat tissue (>50 mg) was available for analysis in 154 of 183 patients with AA amyloidosis and in 354 controls. The sensitivity of amyloid A protein quantification for detection of AA amyloidosis (>11.6 ng/mg fat tissue) was 84% (95% CI: 77 - 89%) and specificity 99% (95% CI: 98 - 100%). Amyloid A protein quantification and semiquantitative Congo red scoring were concordant. Men had lower amyloid A protein values than women (p < 0.0001) and patients with familial Mediterranean fever had lower values than patients with arthritis (p < 0.001) or other inflammatory diseases (p < 0.01). Conclusions. Amyloid A protein quantification in fat tissue is a sensitive and specific method for detection of clinical AA amyloidosis. Advantages are independence from staining quality and observer experience, direct confirmation of amyloid AA type, and potential for quantitative monitoring of tissue amyloid over time. © 2007 Informa UK Ltd.
Authors & Co-Authors
Hazenberg, Bouke P.C.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Bijzet, Johan
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Limburg, Pieter C.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Skinner, Martha M.
United States, Boston
Boston University
Hawkins, Philip Nigel
United Kingdom, London
Ucl Medical School
Butrimienė, Irena
Lithuania, Vilnius
Vilniaus Universitetas
Livneh, Avi
Israel, Tel Hashomer Tel Aviv
Heller Institute of Medical Research
Lesnyak, Olga
Russian Federation, Yekaterinburg
Regional Hospital No. 1
Nasonov, E. L.
Russian Federation, Moscow
V.a. Nasonova Research Institute of Rheumatology
Filipowicz-Sosnowska, Anna
Poland, Warsaw
Instytut Reumatologii Warsaw
Gül, Ahmet
Turkey, Istanbul
İstanbul Tıp Fakültesi
Merlini, Giampaolo
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Wiland, Piotr
Poland, Wroclaw
Railway Hospital
Özdoǧan, Huri
Turkey, Istanbul
Istanbul Üniversitesi
Gorevic, Peter D.
United States, New York
The Mount Sinai Medical Center
Mäiz, Hédi Ben
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Benson, Merrill D.
United States, Indianapolis
Indiana University-purdue University Indianapolis
Direskeneli, Haner
Turkey, Istanbul
Marmara Üniversitesi Tip Fakültesi
Kaarela, Kalevi
Finland, Heinola
Rheumatism Foundation Hospital Finland
Garceau, Denis
Canada, Laval
Neurochem Inc.
Hauck, Wendy
Canada, Laval
Neurochem Inc.
Van Rijswijk, Martin H.
Netherlands, Groningen
Universitair Medisch Centrum Groningen
Statistics
Citations: 39
Authors: 22
Affiliations: 18
Identifiers
Doi:
10.1080/13506120701260224
ISSN:
13506129
e-ISSN:
17442818
Study Approach
Quantitative
Study Locations
Congo
Participants Gender
Male
Female