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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems
Nature Communications, Volume 14, No. 1, Article 7883, Year 2023
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Description
The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance has been critical for pandemic control, however not all countries can currently sustain community pathogen surveillance programs. Wastewater surveillance has proven valuable in high-income settings, but less is known about the utility of water surveillance of pathogens in low-income countries. Here we show how wastewater surveillance of SAR-CoV-2 can be used to identify temporal changes and help determine circulating variants quickly. In Malawi, a country with limited community-based COVID-19 testing capacity, we explore the utility of rivers and wastewater for SARS-CoV-2 surveillance. From May 2020–May 2022, we collect water from up to 112 river or defunct wastewater treatment plant sites, detecting SARS-CoV-2 in 8.3% of samples. Peak SARS-CoV-2 detection in water samples predate peaks in clinical cases. Sequencing of water samples identified the Beta, Delta, and Omicron variants, with Delta and Omicron detected well in advance of detection in patients. Our work highlights how wastewater can be used to detect emerging waves, identify variants of concern, and provide an early warning system in settings with no formal sewage systems. © 2023, The Author(s).
Authors & Co-Authors
Barnes, Kayla G.
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Cambridge
Massachusetts Institute of Technology
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Gauld, Jillian S.
United States, San Diego
Scripps Research Institute
Rigby, Jonathan
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
United States, Bellevue
Institute for Disease Modeling
Kanjerwa, Oscar
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Uzzell, Christopher B.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Anscombe, Catherine
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
United States, Bellevue
Institute for Disease Modeling
Tomkins-Tinch, Christopher H.
United States, Boston
Harvard T.h. Chan School of Public Health
United Kingdom, London
Medical Research Council
Chibwana, Marah G.
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Ashton, Philip M.
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Malawi, Blantyre
Blantyre District Health Office
Jere, Khuzwayo C.
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Malawi, Blantyre
Blantyre District Health Office
United Kingdom, Liverpool
University of Liverpool
Meschke, John Scott
United Kingdom, Liverpool
University of Liverpool
Diggle, Peter J.
United States, Seattle
University of Washington
Cornick, Jennifer E.
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Malawi, Blantyre
Blantyre District Health Office
Chilima, Ben Z.
United Kingdom, Lancaster
Lancaster University
Jambo, Kondwani C.
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
United States, San Diego
Scripps Research Institute
Malawi, Lilongwe
Ministry of Health Malawai
Andersen, Kristian G.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
United States, La Jolla
Scripps Translational Science Institute
Kawalazira, Gift
United States, Cambridge
Harvard University
Paterson, Steve C.
Malawi, Blantyre
Blantyre District Health Office
Nyirenda, Tonney S.
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Malawi, Blantyre
Kamuzu University of Health Sciences
Feasey, Nicholas A.
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
United States, Bellevue
Institute for Disease Modeling
United Kingdom, St Andrews
University of st Andrews
Statistics
Authors: 20
Affiliations: 16
Identifiers
Doi:
10.1038/s41467-023-43047-y
ISSN:
20411723
Research Areas
Covid
Environmental
Study Locations
Malawi