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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ascaris lumbricoids infection as a risk factor for asthma and atopy in rural Bangladeshi children
Tropical Medicine and Health, Volume 42, No. 2, Year 2014
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Description
Controversy persists as to whether helminth infections cause or protect against asthma and atopy. The aim of this study was to investigate the effects of helminth infection on asthma and atopy among Bangladeshi children. A total of 912 children aged 4.5 years (mean = 54.4, range = 53.5-60.8 months) participated in a cross-sectional study nested into a randomized controlled trial in Bangladesh. Ever-asthma, ever-wheezing and current wheezing were identified using the International Study of Asthma and Allergies in Childhood questionnaire. Current helminth infection was defined by the presence of helminth eggs in stools, measured by routine microscopic examination. Repeated Ascaris infection was defined by the presence of anti-Ascaris IgE ≥ 0.70 UA/ml in serum measured by the CAP-FEIA method. Atopy was defined by specific IgE to house dust mite (anti-DP IgE) ≥ 0.70 UA/ml measured by the CAP-FEIA method and/or positive skin prick test (≥ 5 mm). Anti-Ascaris IgE was significantly associated with ever asthma (odds ratio (OR) = 1.86, 95% CI: 1.14-3.04, highest vs. lowest quartile; P for trend 0.016). Anti-Ascaris IgE was also significantly associated with positive anti-DP IgE (OR = 9.89, 95% CI: 6.52-15.00, highest vs. lowest; P for trend < 0.001) and positive skin prick test (OR = 1.69, 95% CI: 1.01-2.81, highest vs. lowest, P for trend 0.076). These findings suggest that repeated Ascaris infection is a risk factor for asthma and atopy in rural Bangladeshi children. Further analysis is required to examine the mechanism of developing asthma and atopy in relation to helminth infection. © 2014 by The Japanese Society of Tropical Medicine.
Authors & Co-Authors
Hawlader, Mohammad Delwer Hossain
Japan, Tsukuba
University of Tsukuba
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Ma, Enbo
Japan, Tsukuba
University of Tsukuba
Itoh, Makotoh
Japan, Nagakute
Aichi Medical University School of Medicine
Arifeen, Shams E.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Persson, Lars Åke Å.
Sweden, Uppsala
Uppsala Universitet
Moore, Sophie E.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Raqib, Rubhana
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Wagatsuma, Yukiko
Japan, Tsukuba
University of Tsukuba
Statistics
Citations: 28
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.2149/tmh.2013-19
ISSN:
13488945
Research Areas
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative