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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Virulence quenching with a prenylated isoflavanone renders the Malagasy legume Dalbergia pervillei resistant to Rhodococcus fascians
Environmental Microbiology, Volume 13, No. 5, Year 2011
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Description
The phytopathogenic Actinomycete Rhodococcus fascians induces leafy galls on a wide range of hosts, causing major economical losses in the ornamentals industry. Although differences in the responsivity occur within species, no plant tested so far could be considered resistant to R. fascians strain D188 infection. Here, we observed that members of the genus Dalbergia, which belong to the Fabaceae, did not develop leafy galls when challenged with R. fascians and we set out to unravel the mechanism of this recalcitrance. Whereas organic extracts of Dalbergia tissues exhibited toxicity towards the bacteria, more importantly, dichloromethane bark extracts inhibited the induction of bacterial virulence gene expression without any apparent loss of viability, illustrating that resistance is likely multifactorial. The virulence quencher was identified as a new prenylated isoflavanone, termed perbergin, and specifically targeted the AttR regulon (a LysR-type transcriptional regulator) which is imperative for the switch of R. fascians from an epiphytic to a pathogenic lifestyle. The mode of action of perbergin demonstrated that just like in Gram-negative host-microbe interactions, also in Gram-positive phytopathogens autoregulation is being targeted by the plant as an efficient means of defence. Moreover, the identification of perbergin opens the path to disease control in affected nurseries. © 2011 Society for Applied Microbiology and Blackwell Publishing Ltd.
Authors & Co-Authors
Rajaonson, Sanda
Belgium, Brussels
Université Libre de Bruxelles
Madagascar, Antananarivo
Université D'antananarivo
Vandeputte, Olivier M.
Belgium, Brussels
Université Libre de Bruxelles
Vereecke, Danny
Belgium, Ghent
Hogeschool Gent
Kiendrebeogo, Martin
Belgium, Brussels
Université Libre de Bruxelles
Burkina Faso, Ouagadougou
University of Ouagadougou
Ralambofetra, Eliane
Madagascar, Antananarivo
Université D'antananarivo
Stévigny, Caroline
Belgium, Brussels
Université Libre de Bruxelles
Duez, Pierre
Belgium, Brussels
Université Libre de Bruxelles
Rabemanantsoa, Christian
Madagascar, Antananarivo
Institut Malgache de Recherches Appliquees Antananarivo
Mol, Adeline
Belgium, Brussels
Université Libre de Bruxelles
Diallo, Billo M.
Belgium, Brussels
Université Libre de Bruxelles
Baucher, Marie
Belgium, Brussels
Université Libre de Bruxelles
El Jaziri, Mondher
Belgium, Brussels
Université Libre de Bruxelles
Statistics
Citations: 18
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1111/j.1462-2920.2011.02424.x
ISSN:
14622912
Research Areas
Genetics And Genomics