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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impact of smear microscopy results and observed therapy on tuberculosis treatment in Mombasa, Kenya
International Journal of Tuberculosis and Lung Disease, Volume 15, No. 12, Year 2011
Notification
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Description
SETTING: Tuberculosis (TB) treatment center at Coast Provincial General Hospital in Mombasa, Kenya. OBJECTIVES: To describe TB management practices in a facility in coastal Kenya and identify factors associated with poor treatment outcomes. DESIGN: Retrospective review of patient treatment records from January 2008 to June 2009. Treatment outcomes of patients were classified as treatment success (cure or treatment completion) or poor treatment outcome (treatment failure, death or default). Relative risk regression was used to determine the association between exposures of interest and poor treatment outcomes. RESULTS: Records were obtained from a total of 183 patients: 142 (78%) had pulmonary TB, 68 (37%) were human immunodeficiency virus (HIV) infected and 81 (44%) had acid-fast bacilli (AFB) positive smear microscopy. Most treated individuals (86%) achieved a successful treatment outcome as defined by the World Health Organization. Of those with poor treatment outcomes, 64% defaulted, 32% died, and 4% failed treatment. Initial negative AFB smear and HIV co-infection were associated with poor treatment outcomes (RR 3.32, 95%CI 1.22-8.99 and RR 4.61, 95%CI 1.69-12.59, respectively). CONCLUSION: Strategies to accelerate accurate diagnosis of smear-negative TB and increase patient retention during treatment, especially in HIV co-infected individuals, are needed to reduce poor treatment outcomes in Kenya. © 2011 The Union.
Authors & Co-Authors
Arentz, Matthew
United States, Seattle
University of Washington
Narita, M.
United States, Seattle
University of Washington
United States, Seattle
Seattle King County Department of Public Health
Sangaré, Laura R.
United States, Seattle
University of Washington
Kah, J. F.
United States, Seattle
University of Washington School of Medicine
Low, D.
United States, Claremont
Pomona College
Mandaliya, Kishor N.
Kenya, Mombasa
Coast Provincial General Hospital, Kenya
Amukoye, Evans Inyangala
Kenya, Nairobi
Kenya Medical Research Institute
Sitienei, Joseph K.
Kenya, Nairobi
Ministry of Public Health and Sanitation
Walson, Judd L.
United States, Seattle
University of Washington
Kenya, Nairobi
Kenya Medical Research Institute
Statistics
Citations: 9
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.5588/ijtld.10.0625
ISSN:
10273719
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Locations
Kenya