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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Contribution of HIV infection to mortality among cancer patients in Uganda
AIDS, Volume 27, No. 18, Year 2013
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Description
Objective: HIV infection is associated with cancer risk. This relationship has resulted in a growing cancer burden, especially in resource-limited countries where HIV is highly prevalent. Little is known, however, about how HIV affects cancer survival in these settings. We therefore investigated the role of HIV in cancer survival in Uganda. Design: Retrospective cohort (N=802). Methods: Eligible cancer patients were residents of Kyadondo County, at least 18 years of age at cancer diagnosis, and diagnosed between 2003 and 2010 with one of the following: breast cancer, cervical cancer, non-Hodgkin's lymphoma, Hodgkin's lymphoma, or esophageal cancer. Patients were classified as HIV-infected at cancer diagnosis based on a documented positive HIV antibody test, medical history indicating HIV infection, or an HIV clinic referral letter. The primary outcome, vital status at 1 year following cancer diagnosis, was abstracted from the medical record or determined through linkage to the national hospice database. The risk of death during the year after cancer diagnosis was compared between cancer patients with and without evidence of HIV infection using Cox proportional hazards regression. Results: HIV-infected cancer patients in Uganda experienced a more than two-fold increased risk of death during the year following cancer diagnosis compared to HIVuninfected cancer patients [hazard ratio 2.28; 95% confidence interval (CI) 1.61-3.23]. This association between HIV and 1-year cancer survival was observed for both cancers with (hazard ratio 1.56; 95% CI 1.04-2.34) and without (hazard ratio 2.68; 95% CI 1.20-5.99) an infectious cause. Conclusion: This study demonstrates the role of HIV in cancer survival for both cancers with and without an infectious cause in a resource-limited, HIV-endemic setting. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Coghill, Anna E.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
United States, Rockville
National Cancer Institute Nci
Newcomb, Polly A.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Madeleine, Margaret M.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Richardson, Barbra Ann
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Mutyaba, Innocent O.
Uganda, Kampala
Uci/hutchinson Cancer Center Alliance
Okuku, Fred Macho
Uganda, Kampala
Uci/hutchinson Cancer Center Alliance
Phipps, Warren T.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Uganda, Kampala
Uci/hutchinson Cancer Center Alliance
Wabinga, Henry R.
Uganda, Kampala
Kampala Cancer Registry
Orem, Jackson
United States, Seattle
Fred Hutchinson Cancer Research Center
Uganda, Kampala
Uci/hutchinson Cancer Center Alliance
Casper, Corey
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Uganda, Kampala
Uci/hutchinson Cancer Center Alliance
Statistics
Citations: 67
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1097/01.aids.0000433236.55937.cb
e-ISSN:
14735571
Research Areas
Cancer
Environmental
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Locations
Uganda