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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Novel baculovirus-derived p67 subunit vaccines efficacious against East Coast fever in cattle
Vaccine, Volume 23, No. 21, Year 2005
Notification
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Description
Two novel baculovirus-derived recombinant Theileria parva p67 constructs were tested for their vaccine potential against East Coast fever. Boran calves were immunized with a his-GFP-p67 fusion protein (GFP:p67ΔSS) or with GP64:p67C, a protein fusion between a C-terminal domain of p67 and the baculovirus envelope protein GP64. Both GFP:p67ΔSS and GP64:p67C induced antibodies with high ELISA titers that neutralized T. parva sporozoites with high efficiency. Upon challenge, a correlation was observed between the in vitro neutralizing capacity and the reduction in severe ECF for individual animals. A protection level upto 85% was obtained. This level of protection was achieved with only two inoculations of 100 μg per dose, which is a major improvement over previous recombinant p67 products. © 2004 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Kaba, Stephen A.
Unknown Affiliation
Musoke, Anthony Jim Tony
Unknown Affiliation
Schaap, Dick
Unknown Affiliation
Schetters, Theo P.M.
Unknown Affiliation
Rowlands, John
Unknown Affiliation
Vermeulen, Arno N.
Unknown Affiliation
Nene, Vishvanath M.
Unknown Affiliation
Vlak, Just M.
Unknown Affiliation
Van Oers, Monique M.
Unknown Affiliation
Statistics
Citations: 22
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/j.vaccine.2004.10.043
ISSN:
0264410X