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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
dentistry
Enhancing mandibular bone regeneration and perfusion via axial vascularization of scaffolds
Clinical Oral Investigations, Volume 18, No. 6, Year 2014
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Description
Objective: Reconstruction of large and complex bone segments is a challenging problem facing maxillofacial surgery. The majority of current regenerative approaches rely on extrinsic vascularization, which is deficient after cancer ablation and irradiation. The aim of the study was to investigate the efficacy of intrinsic axial vascularization of synthetic bone scaffolds in the management of critical-size mandibular defects. Materials and methods: Scaffold-guided mandibular regeneration in two groups of adult male goats was compared. Only the scaffolds of the second group were axially vascularized via in situ embedding of an arteriovenous loop through microsurgical anastomosis of facial vessels. After 6 months of follow up, both groups were compared through radiological, biomechanical, histological and histomorphometric analysis. Results: The axially vascularized constructs have showed significantly more central vascularization (p = 0.021) and markedly enhanced central bone formation (p = 0.08). The biomechanical characteristics were enhanced, but the difference between both groups was not statistically significant (p = 0.98). Conclusions: Axially vascularized synthetic mandibular grafts show better vascularization at their central regions, permitting more efficient bone regeneration. Clinical relevance: The encouraging results of the proposed technique could be of benefit in optimizing the reconstruction of large critical-size bone defects. © 2013 Springer-Verlag Berlin Heidelberg.
Authors & Co-Authors
Eweida, Ahmad Mahmoud
Egypt, Alexandria
Faculty of Medicine
Egypt, Alexandria
Faculty of Engineering
Nabawi, Ayman Sameh
Egypt, Alexandria
Faculty of Medicine
Abouarab, Mohamed H.
Egypt, Alexandria
Alexandria University
Kayed, Mohamed Hamdy
Egypt, Alexandria
Alexandria University
Elhammady, Habashi A.
Egypt, Alexandria
Faculty of Medicine
Etaby, Ashraf N.
Egypt, Alexandria
Alexandria University
Khalil, Mohamed Rafik
Egypt, Alexandria
Faculty of Medicine
Shawky, Michael Samir
Egypt, Alexandria
Faculty of Medicine
Kneser, Ulrich
Germany, Heidelberg
Universität Heidelberg
Germany, Ludwigshafen
Bg Trauma Center
Horch, Raymund E.
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Germany, Erlangen
Universitätsklinikum Erlangen
Nagy, Naglaa B.
Egypt, Alexandria
Faculty of Engineering
Egypt, Tanta
Tanta University
Marei, Mona Kamal
Egypt, Alexandria
Faculty of Engineering
Egypt, Alexandria
Faculty of Dentistry
Statistics
Citations: 12
Authors: 12
Affiliations: 9
Identifiers
Doi:
10.1007/s00784-013-1143-8
ISSN:
14326981
e-ISSN:
14363771
Research Areas
Cancer
Health System And Policy
Participants Gender
Male