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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Purification, synthesis and characterization of AaCtx, the first chlorotoxin-like peptide from Androctonus australis scorpion venom
Peptides, Volume 32, No. 4, Year 2011
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Description
AaCtx is the first chlorotoxin-like peptide isolated from Androctonus australis scorpion venom. Its amino acid sequence shares 70% similarity with chlorotoxin from Leiurus quinquestriatus scorpion venom, from which it differs by twelve amino acids. Due to its very low concentration in venom (0.05%), AaCtx was chemically synthesized. Both native and synthetic AaCtx were active on invasion and migration of human glioma cells. However, their activity was found to be lower than that of chlorotoxin. The molecular model of AaCtx shows that most of amino acids differing between AaCtx and chlorotoxin are localized on the N-terminal loop and the α-helix. Based on known compounds that block chloride channels, we suggest that the absence of negative charged amino acids on AaCtx structure may be responsible for its weak activity on glioma cells migration and invasion. This finding serves as a starting point for structure-function relationship studies leading to design high specific anti-glioma drugs. © 2011 Elsevier Inc.
Authors & Co-Authors
Rjeibi, Ilhem
Tunisia, Tunis
Institut Pasteur de Tunis
Mabrouk, Kamel
France, Marseille
Aix Marseille Université
Mosrati, Hend
Tunisia, Tunis
Institut Pasteur de Tunis
Bérenguer, Caroline
France, Beziers
Centre de Recherche en Oncologie Biologique et Onco-pharmacologie
Mejdoub, Hafedh
Tunisia, Sfax
Faculté Des Sciences de Sfax
Villard, Claude
France, Beziers
Centre de Recherche en Oncologie Biologique et Onco-pharmacologie
Laffitte, Daniel
France, Beziers
Centre de Recherche en Oncologie Biologique et Onco-pharmacologie
Bertin, Denis
France, Marseille
Aix Marseille Université
Ouafik, ’L'houcine H.
France, Beziers
Centre de Recherche en Oncologie Biologique et Onco-pharmacologie
Luis, José
France, Beziers
Centre de Recherche en Oncologie Biologique et Onco-pharmacologie
ElAyeb, Mohamed
Tunisia, Tunis
Institut Pasteur de Tunis
Srairi-Abid, Najet
Tunisia, Tunis
Institut Pasteur de Tunis
Statistics
Citations: 44
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1016/j.peptides.2011.01.015
ISSN:
01969781