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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Diagnostic concordance of breast pathologists: lessons from the National Health Service Breast Screening Programme Pathology External Quality Assurance Scheme
Histopathology, Volume 70, No. 4, Year 2017
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Description
Aims: Previous concordance studies examining accuracy of breast diagnosis by pathologists, typically targeting difficult, histologically challenging breast lesions using artificial and restrictive environments, have reported aberrantly high levels of diagnostic discordance. The results of these studies may be misinterpreted by non-pathologists and raise concerns relating to routine practice. This study aims to assess the diagnostic agreement among UK breast pathologists. Methods: Two hundred and forty consecutive breast lesions, submitted by participants from their routine practice, included in the UK National Health Service Breast Screening Programme (NHSBSP) breast pathology EQA scheme during the last 10 years were reviewed. An average of approximately 600 participants viewed each case. Data on diagnostic categories (benign, atypical, in-situ malignant and invasive malignant) were collected. In this study, benign and atypical diagnoses were grouped together. Results: The overall diagnostic agreement level was in the almost perfect range. Thirty-five cases (14.6%) showed diagnostic concordance of ≤95%. Reasons for discordance included one or more of: (1) scheme methodology limitations such as: (i) miscoding of certain lesions (e.g. phyllodes tumours and lobular neoplasia) (n = 7) and (ii) variable representation of the index lesion on glass slides (n = 18); and (2) diagnostically challenging cases that may be interpreted more easily using immunohistochemistry (n = 28). These latter included benign and malignant papillary lesions (n = 12), complex sclerosing lesions (n = 7), intraductal epithelial proliferative lesions (n = 6) and an unusual special tumour type (n = 1). Further review identified pathologists’ misinterpretation in 13 cases (5.4%), with an average discordance rate of only 4.2%. Conclusions: The performance of breast pathologists is high. Exclusion of the effect of the scheme methodology limitations highlights further the high performance rate and identifies true diagnostically challenging entities. These difficult cases may benefit from additional diagnostic work-up and second opinions. © 2016 John Wiley & Sons Ltd
Authors & Co-Authors
Rakha, Emad A.
United Kingdom, Nottingham
Nottingham City Hospital
Ahmed, Mohamed A.H.
United Kingdom, Nottingham
Nottingham City Hospital
Aleskandarany, Mohammed A.
United Kingdom, Nottingham
Nottingham City Hospital
Hodi, Zsolt
United Kingdom, Nottingham
Nottingham City Hospital
Lee, Andrew H.S.
United Kingdom, Nottingham
Nottingham City Hospital
Pinder, S. E.
United Kingdom, London
King's College London
Ellis, Ian O.
United Kingdom, Nottingham
Nottingham City Hospital
Statistics
Citations: 21
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1111/his.13117
ISSN:
03090167
Research Areas
Cancer