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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Oxidative damage and alterations in antioxidant enzyme activities in the kidneys of rat exposed to trichloroacetic acid: Protective role of date palm fruit
Journal of Physiology and Biochemistry, Volume 70, No. 2, Year 2014
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Description
In this study, we investigated the antioxidant and protective properties of date fruit aqueous extract (DFAE) on trichloroacetic acid (TCA)-induced nephrotoxicity in rat. Oral administration of TCA as drinking water (0.5 and 2 g/L) daily for 2 months caused nephrotoxicity as evident by elevated levels of plasma creatinine, urea, and uric acid. Activity of antioxidant enzymes, catalase (CAT) and glutathione peroxidase (GPx), was decreased, whereas superoxide dismutase (SOD) activity and malondialdehyde (MDA) level were increased along with histopathological injuries. The oral administration of DFAE (4 mL/kg/day) to TCA-treated groups proved some significant correction by increasing the antioxidant activity of the CAT and GPx enzymes and normalizing the SOD activity and the MDA level (p <0.05). It also protected kidney's histology and normalized the functions of this organ. It could be concluded that DFAE has a protective role against TCA-induced oxidative stress in rat, thereby protecting the renal tissue from TCA-induced damage. © University of Navarra 2013.
Authors & Co-Authors
El Arem, Amira
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Zekri, Mouna
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Thouri, Amira
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Saafi, Emna Behija
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Ghrairi, Fatma
Tunisia, Monastir
Université de Monastir
Ayed, Amel
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Zakhama, Abdelfattah
Tunisia, Monastir
Chu Fattouma-bourguiba
Achour, Lotfi
Tunisia, Monastir
Institut Supérieur de Biotechnologie de Monastir
Statistics
Citations: 16
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1007/s13105-013-0302-3
ISSN:
11387548
e-ISSN:
18778755
Research Areas
Environmental
Health System And Policy
Violence And Injury