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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Cutting Edge: SARS-CoV-2 Infection Induces Robust Germinal Center Activity in the Human Tonsil
Journal of Immunology, Volume 208, No. 10, Year 2022
Notification
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Description
Understanding the generation of immunity to SARSCoV- 2 in lymphoid tissues draining the site of infection has implications for immunity to SARS-CoV-2. We performed tonsil biopsies under local anesthesia in 19 subjects who had recovered from SARS-CoV-2 infection 24-225 d previously. The biopsies yielded >3 million cells for flow cytometric analysis in 17 subjects. Total and SARS-CoV-2 spike-specific germinal center B cells, and T follicular helper cells, were readily detectable in human tonsils early after SARS-CoV-2 infection, as assessed by flow cytometry. Responses were higher in samples within 2 mo of infection but still detectable in some subjects out to 7 mo following infection. We conclude the tonsils are a secondary lymphoid organ that develop germinal center responses to SARS-CoV-2 infection and could play a role in the long-term development of immunity. © 2022 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Lau, Jillian S.Y.
Australia, Melbourne
The Alfred
Australia, Clayton
Monash Medical Centre
Flanagan, Katie L.
Australia, Hobart
University of Tasmania
Australia, Clayton
Monash University
Australia, Melbourne
Rmit University
Australia, Launceston
Launceston General Hospital
Kedzierska, Katherine
Australia, Melbourne
University of Melbourne
McMahon, James H.
Australia, Melbourne
The Alfred
Australia, Clayton
Monash Medical Centre
Wheatley, Adam Kenneth
Australia, Melbourne
University of Melbourne
Juno, Jennifer A.
Australia, Melbourne
University of Melbourne
Kent, Stephen J.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
The Alfred
Statistics
Citations: 4
Authors: 7
Affiliations: 8
Identifiers
Doi:
10.4049/jimmunol.2101199
ISSN:
00221767