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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
The effect of single dose versus two doses of praziquantel on Schistosoma haematobium infection and pathology among school-aged children in Mali
Parasitology, Volume 136, No. 13, Year 2009
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Description
The aim of this study was to assess the effect of two doses of 40 mg/kg praziquantel with 2 weeks interval versus a standard single dose of 40 mg/kg on cure rates, egg reduction, intensity of infection, and micro-haematuria in Schistosoma haematobium infections. A randomised controlled intervention study was carried out among school-aged children in two different endemic settings with follow-up at 3, 6 and 18 months following drug administration. Differences in cure rates between the two treatment regimens were not significant. However, in high transmission areas, the double treatment regimen was more effective in egg reduction than single treatment regimen and the difference in egg reduction between the two treatments was significant at 3 months (P<0005), 6 months (P<00001) and 18 months (P<0003) after treatment. There was a significant difference in the effect of the two treatments on prevalence of micro-haematuria at 18-month follow-up in both Koulikoro (P<0001) and Selingue (P<0003). The study shows that although no significant difference could be observed in the overall cure-rates between the two treatment regimens, the effect of double treatment was a significant reduction in infection intensity as well as micro-haematuria which may have a great impact in reducing subtle morbidity. Copyright © 2009 Cambridge University Press.
Authors & Co-Authors
Sacko, Moussa
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Magnussen, Pascal
Denmark, Copenhagen
Dbl -center for Health Research and Development
Traorŕ, M.
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Mali
Université de Bamako
Landouré, Aly
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Doucouré, Aïssata
Mali, Bamako
Institut National de Recherche en Sante Publique Mali
Reimert, Claus Michael
Denmark, Copenhagen
Dbl -center for Health Research and Development
Vennervald, Birgitte Jyding
Denmark, Copenhagen
Dbl -center for Health Research and Development
Statistics
Citations: 21
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1017/S0031182008000486
e-ISSN:
14698161
Research Areas
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Locations
Mali