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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
P53 Mutations in hepatocellular carcinoma patients in Egypt
International Journal of Hygiene and Environmental Health, Volume 208, No. 4, Year 2005
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Description
The p53 gene plays a major role in hepatocellular carcinoma (HCC). Acquired mutations may provide clues to etiology, as some carcinogenic agents are associated with specific genetic changes in p53. Our aim was to analyze the spectrum of p53 mutations in tumor tissues from subjects with HCC in Egypt, where there is a rising incidence of HCC due to hepatitis C virus (HCV). We collected tumor tissues from 41 subjects with HCC diagnosed at the National Cancer Institute of Cairo University during 2000-2003. Sequence mutations were analyzed by the Affymetrix GeneChip technique. HCV RNA was detected in the sera of 37 subjects (90%). Only one patient had a current HBV infection. A total of 17 of the 41 subjects (41%) had p53 mutations. Thirteen of these were in exon 7, of which 10 were in codon 249, but only 8 of the 10 were the R249S mutation, previously reported to be associated with aflatoxin exposure. The other three exon 7 mutations were found in codons 232, 242 and 248. A total of three mutations were detected in exon 5 codons 133, 144 and 176. One mutation was detected in exon 8 codon 275. Unlike previous studies, this population is characterized by a high prevalence of chronic HCV infection. The presence of the R249S mutation in exon 7 may indicate that these subjects with HCC have been exposed to aflatoxin (AFB1), and further investigation is in progress to measure AFB1-albumin adducts in the sera of these subjects. © 2005 Elsevier GmbH. All rights reserved.
Authors & Co-Authors
A El-Kafrawy, Sherif Aly
Egypt, Shibin el Kom
Menoufia University
Abdel-Hamid, Mohamed A.
Egypt, Minya
Minia University
El-Daly, Maï Mohamed
Egypt, Shibin el Kom
Menoufia University
Nada, Ola Hassan
Egypt, Cairo
Ain Shams University
Ismail, Alaa E.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
Ezzat, Sameera
Egypt, Shibin el Kom
Menoufia University
Abdel-Latif, Soheir
Egypt, Giza
Cairo University
Abdel-Hamid, Amany
Egypt, Giza
Cairo University
Shields, Peter G.
United States, Washington, D.c.
Georgetown Lombardi Comprehensive Cancer Center
Loffredo, Christopher A.
United States, Washington, D.c.
Georgetown Lombardi Comprehensive Cancer Center
United States, Washington, D.c.
Georgetown University
Statistics
Citations: 32
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1016/j.ijheh.2005.02.002
ISSN:
14384639
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Egypt