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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Adaptive Selection on Bracovirus Genomes Drives the Specialization of Cotesia Parasitoid Wasps
PLoS ONE, Volume 8, No. 5, Article e64432, Year 2013
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Description
The geographic mosaic of coevolution predicts parasite virulence should be locally adapted to the host community. Cotesia parasitoid wasps adapt to local lepidopteran species possibly through their symbiotic bracovirus. The virus, essential for the parasitism success, is at the heart of the complex coevolutionary relationship linking the wasps and their hosts. The large segmented genome contained in the virus particles encodes virulence genes involved in host immune and developmental suppression. Coevolutionary arms race should result in the positive selection of particular beneficial alleles. To understand the global role of bracoviruses in the local adaptation or specialization of parasitoid wasps to their hosts, we studied the molecular evolution of four bracoviruses associated with wasps of the genus Cotesia, including C congregata, C vestalis and new data and annotation on two ecologically differentiated populations of C sesamie, Kitale and Mombasa. Paired orthologs analyses revealed more genes under positive selection when comparing the two C sesamiae bracoviruses belonging to the same species, and more genes under strong evolutionary constraint between species. Furthermore branch-site evolutionary models showed that 17 genes, out of the 54 currently available shared by the four bracoviruses, harboured sites under positive selection including: the histone H4-like, a C-type lectin, two ep1-like, ep2, a viral ankyrin, CrV1, a ben-domain, a Serine-rich, and eight unknown genes. Lastly the phylogenetic analyses of the histone, ep2 and CrV1 genes in different African C sesamiae populations showed that each gene described differently the individual relationships. In particular we found recombination had happened between the ep2 and CrV1 genes, which are localized 37.5 kb apart on the wasp chromosomes. Involved in multidirectional coevolutionary interactions, C sesamiae wasps rely on different bracovirus mediated molecular pathways to overcome local host resistance. © 2013 Jancek et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3665748/bin/pone.0064432.s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3665748/bin/pone.0064432.s002.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3665748/bin/pone.0064432.s003.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3665748/bin/pone.0064432.s004.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3665748/bin/pone.0064432.s005.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3665748/bin/pone.0064432.s006.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3665748/bin/pone.0064432.s007.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3665748/bin/pone.0064432.s008.docx
Authors & Co-Authors
Jancek, Séverine
France, Tours
Université de Tours
Bézier, Annie
France, Tours
Université de Tours
Gayral, Philippe
France, Tours
Université de Tours
Paillusson, Corentin
France, Tours
Université de Tours
Kaiser, Laure
France, Gif-sur-yvette
Evolution, Génomes, Comportement et Ecologie
France, Versailles
Physiologie de L'insecte Signalisation et Communication
Dupas, Stéphane
France, Gif-sur-yvette
Evolution, Génomes, Comportement et Ecologie
Le Rû, Bruno Pierre
France, Gif-sur-yvette
Evolution, Génomes, Comportement et Ecologie
Kenya, Nairobi
International Centre of Insect Physiology and Ecology Nairobi
Barbe, Valérie
France, Evry
Université D'evry Val D'essonne
Periquet, G.
France, Tours
Université de Tours
Drezen, Jean Michel
France, Tours
Université de Tours
Herniou, Elisabeth A.
France, Tours
Université de Tours
Statistics
Citations: 50
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0064432
e-ISSN:
19326203
Research Areas
Genetics And Genomics